SCHEMBL4970877

SCHEMBL4970877

O=CCCN1C(=O)C(c2ccccc2)Oc2ccc(Cl)cc21

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
F10 P00742 7/20 0.44
ALOX15 P16050 1/20 0.44
HSD17B10 Q99714 1/20 0.44
REN P00797 1/20 0.40
MAPT P10636 3/20 0.40
GSK3B P49841 2/20 0.39
ADK P55263 2/20 0.39
TSHR P16473 2/20 0.39
HTT P42858 1/20 0.39
KMT2A Q03164 1/20 0.38
PRSS1 P07477 3/20 0.38
KMO O15229 1/20 0.38
RAB9A P51151 1/20 0.37
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
CYP19A1 P11511 1/20 0.36
PIM1 P11309 1/20 0.35
PLG P00747 2/20 0.35
F2 P00734 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4969888 0.92 F10 (0.46) F10ALOX15HSD17B10MAPTGSK3B
SCHEMBL4970062 0.86 F10 (0.45) F10RENTSHRKMT2APRSS1
SCHEMBL4972118 0.83 KMO (0.57) F10ALOX15HSD17B10RENMAPT
SCHEMBL4970028 0.80 F10 (0.47) F10RENGSK3BKMT2APRSS1
SCHEMBL7123252 0.78 F10 (0.59) F10PRSS1PLGF2
SCHEMBL4967488 0.75 KMO (0.47) F10ALOX15HSD17B10MAPTGSK3B
SCHEMBL4970013 0.74 F10 (0.39) F10RENTSHRKMT2APRSS1
SCHEMBL4969922 0.74 F10 (0.43) F10HTTKMT2APRSS1RAB9A
SCHEMBL4970579 0.74 F10 (0.40) F10RENGSK3BADKKMT2A
SCHEMBL4969051 0.73 F10 (0.42) F10RENHTTKMT2APRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1985297-A1 CARBOXYLIC ACID COMPOUND AND USE THEREOF Japan Tobacco, Inc. (JP) 2008-10-29 EP disclosed
US-20070197512-A1 Carboxylic Acid Compounds and Use Thereof JAPAN TOBACCO INC. (JP) 2007-08-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197512-A1 Carboxylic Acid Compounds and Use Thereof GLS, SLC10A1, SOAT1 F10 4290/4885ALOX15 443/4885HSD17B10 380/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.