Urea

Urea

SCHEMBL4970936

NC(N)=O.O=S(=O)(O)c1cccc(-c2ccccc2)c1S(=O)(=O)O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 2/20 0.46
SLC9A1 P19634 2/20 0.41
CASP1 P29466 2/20 0.40
FGFR1 P11362 1/20 0.40
SRC P12931 1/20 0.40
FGFR2 P21802 1/20 0.40
FGFR4 P22455 1/20 0.40
FGFR3 P22607 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
TTR P02766 2/20 0.40
HNF4A P41235 1/20 0.40
DAPK1 P53355 1/20 0.37
CHAT P28329 1/20 0.37
SNCA P37840 1/20 0.37
CYP1A2 P05177 1/20 0.37
PTGS2 P35354 1/20 0.37
CYP2D6 P10635 1/20 0.36
FABP4 P15090 1/20 0.36
CCNA2 P20248 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30166530 0.93 TSHR (0.41) BCAT2CASP1TTRHNF4ADAPK1
SCHEMBL392931 0.93 TSHR (0.41) BCAT2CASP1TTRHNF4ADAPK1
Hydrochloric Acid SCHEMBL11760140 0.91 PTGS2 (0.40) BCAT2SLC9A1CASP1TTRHNF4A
Phthalic Acid SCHEMBL8745684 0.87 HNF4A (0.53) BCAT2HNF4ACYP2D6FABP4TSHR
SCHEMBL27690669 0.86 STAT3 (0.44) BCAT2PTGS2CDK2
(Z)-1,2-Diphenylethene SCHEMBL28265888 0.83 PTPN1 (0.44) CASP1TTRCHATSNCACYP1A2
SCHEMBL21794264 0.83 TSHR (0.46) BCAT2SLC9A1FGFR1FGFR2FGFR4
Ether SCHEMBL2731657 0.81 PTGS2 (0.37) SLC9A1CASP1TTRCHATSNCA
SCHEMBL460175 0.80 HNF4A (0.38) BCAT2CASP1TTRHNF4ADAPK1
SCHEMBL2731656 0.79 CASP1 (0.37) BCAT2CASP1TTRHNF4ACHAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030181416-A1 Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof TRIDENT GROWTH FUND, LP 2003-09-25 US claimed
EP-1718315-A4 HIGH DOSE, SHORT INTERVAL USE OF SULFATED POLYSACCHARIDES FOR THE TREATMENT OF INFECTIONS UNIV MONASH (AU) 2008-08-13 EP disclosed
US-20080004236-A1 High Dose, Short Interval Use of Sulfated Polysaccharides for Treatment of Infections COMPER WAYNE D 2008-01-03 US disclosed
US-20070027109-A1 Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof MONASH UNIVERSITY 2007-02-01 US disclosed
EP-1718315-A1 HIGH DOSE, SHORT INTERVAL USE OF SULFATED POLYSACCHARIDES FOR THE TREATMENT OF INFECTIONS Monash University (AU) 2006-11-08 EP disclosed
US-20060084631-A1 Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof MONASH UNIVERSITY 2006-04-20 US disclosed
EP-1062325-B1 PURIFICATION OF VIRUS PREPARATIONS CANTAB PHARMACEUTICALS RES LTD (GB) 2006-01-25 EP disclosed
WO-2006003521-A1 HIGH DOSE, SHORT INTERVAL USE OF SULFATED POLYSACCHARIDES FOR THE TREATMENT OF INFECTIONS MONASH UNIVERSITY (US) 2006-01-12 WO disclosed
WO-2005004882-A1 ANTIVIRAL CHARGED POLYMERS THAT EXHIBIT RESISTANCE TO LYSOSOMAL DEGRADATION DURING KIDNEY FILTRATION AND RENAL PASSAGE, COMPOSITIONS AND METHODS OF USE THEREOF MONASH UNIVERSITY (AU) 2005-01-20 WO disclosed
US-20050009782-A1 Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof TRIDENT GROWTH FUND, LP 2005-01-13 US disclosed
US-20050004071-A1 Charged polysaccharides resistant to lysosomal degradation during kidney filtration and renal passage and their use to treat or prevent infection by coronaviruses TRIDENT GROWTH FUND, LP 2005-01-06 US disclosed
WO-2004093888-A1 CHARGED POLYSACCHARIDES RESISTANT TO LYSOSOMAL DEGRADATION DURING KIDNEY FILTRATION AND RENAL PASSAGE AND THEIR USE TO TREAT OR PREVENT INFECTION BY CORONAVIRUSES MONASH UNIVERSITY (AU) 2004-11-04 WO disclosed
US-20040009953-A1 Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof TRIDENT GROWTH FUND, LP 2004-01-15 US disclosed
US-20030181416-A1 Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof TRIDENT GROWTH FUND, LP 2003-09-25 US disclosed
US-6267967-B1 Virus preparations and methods CANTAB PHARMACEUTICALS RESEARCH LIMITED (GB) 2001-07-31 US disclosed
EP-1062325-A2 PURIFICATION OF VIRUS PREPARATIONS CANTAB PHARMACEUTICALS RESEARCH LIMITED (GB) 2000-12-27 EP disclosed
WO-1999045104-A2 PURIFICATION OF VIRUS PREPARATIONS CANTAB PHARMACEUTICALS RESEARCH LIMITED (GB) 1999-09-10 WO disclosed