Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL3591976 | 0.91 | ACHE (0.41) | TSHRALDH1A1 | |
| SCHEMBL2876460 | 0.78 | — | — | |
| SCHEMBL5523766 | 0.78 | — | — | |
| SCHEMBL14778273 | 0.78 | — | — | |
| SCHEMBL22319333 | 0.76 | KDM4E (0.38) | — | |
| SCHEMBL20983462 | 0.76 | — | — | |
| SCHEMBL2497339 | 0.76 | RIPK1 (0.32) | — | |
| SCHEMBL19473677 | 0.74 | ALDH1A1 (0.33) | TSHRALDH1A1 | |
| SCHEMBL16760834 | 0.74 | — | — | |
| SCHEMBL1979249 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101983198-A | Pyrido [4, 3-d] pyrimidinone derivatives as kinase inhibitors | IRM LLC | 2011-03-02 | — | — | CN | claimed |
| CN-110382470-B | Preparation method of efavirenz | 纳尔逊·曼德拉都市大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-115413275-A | Substituted 1,1 , -biphenyl compounds and methods of use thereof | 爱彼特生物制药公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-20220185810-A1 | Novel Process for the Preparation of Filgotinib and Intermediates Thereof | UNICHEM LABORATORIES LIMITED (IN) | 2022-06-16 | — | — | US | disclosed |
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2022-05-05 | — | — | US | disclosed |
| EP-3947381-A2 | NOVEL PROCESS FOR THE PREPARATION OF FILGOTINIB AND INTERMEDIATES THEREOF | Unichem Laboratories Ltd (IN) | 2022-02-09 | — | — | EP | disclosed |
| CN-113677676-A | Novel method for preparing non-gautinib and intermediate thereof | 联合化学实验室有限公司 | 2021-11-19 | — | — | CN | disclosed |
| CN-113613724-A | Compounds useful in HIV therapy | 葛兰素史克知识产权开发有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-113444111-A | Novel benzodiazepine derivative and use thereof | 尹图赛利有限公司 | 2021-09-28 | — | — | CN | disclosed |
| US-5523407-A | ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE INHIBITORS, FOR TREATING OR PREVENTING HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, CARDIOVASCULAR DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| US-5362742-A | Acyl CoA: cholesterol acyltransferase | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-11-08 | — | — | US | disclosed |
| US-5318969-A | Hypotensive, vasodilating action and muscle relaxants | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0505565-B1 | QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-04-27 | — | — | EP | disclosed |
| EP-0339562-B1 | BENZOPYRAN COMPOUND AND ITS PHARMACEUTICAL USE | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1993-09-15 | — | — | EP | disclosed |
| EP-0505565-A1 | QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE. | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-09-30 | — | — | EP | disclosed |
| US-5143936-A | Benzopyran compound and its pharmaceutical use | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1992-09-01 | — | — | US | disclosed |
| WO-1991009017-A1 | QUINOLINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-27 | — | — | WO | disclosed |
| US-5021432-A | Hypotensive agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0339562-A1 | Benzopyran compound and its pharmaceutical use | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185810-A1 | Novel Process for the Preparation of Filgotinib and Intermediates Thereof | ABL1, JAK1, JAK3 | TSHR 868/4885ALDH1A1 3728/4885HMGCR 1994/4885 |
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | TSHR 3913/4885ALDH1A1 3245/4885HMGCR 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.