Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | AQP1 | P29972 | 3/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828783 | 0.88 | SIRT2 (0.32) | HTR7ALDH1A1 | |
| SCHEMBL5140412 | 0.87 | AQP1 (0.37) | AQP1MEN1HSP90AA1KMT2A | |
| SCHEMBL4710394 | 0.79 | CNR1 (0.38) | HTR1AHTR7AQP1PLA2G7PARP1 | |
| SCHEMBL4596402 | 0.78 | PLA2G7 (0.35) | HTR1AHTR7AQP1PLA2G7PARP1 | |
| SCHEMBL4226327 | 0.78 | AQP1 (0.55) | HTR1AHTR7AQP1PLA2G7PARP1 | |
| SCHEMBL4791170 | 0.78 | AQP1 (0.39) | AQP1ALDH1A1MAPTMEN1HSP90AA1 | |
| SCHEMBL4863731 | 0.76 | NUDT1 (0.39) | AQP1 | |
| SCHEMBL4235651 | 0.76 | AQP1 (0.45) | HTR1AHTR7AQP1PLA2G7ALDH1A1 | |
| SCHEMBL4235648 | 0.76 | AQP1 (0.60) | AQP1PLA2G7PARP1MAPT | |
| SCHEMBL4790587 | 0.74 | AQP1 (0.63) | HTR1AHTR7AQP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879569-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | Wyeth (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006116221-A2 | THERAPEUTIC COMBINATIONS FOR THE TREATMENT OR PREVENTION OF PSYCHOTIC DISORDERS | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |