Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970977 | 0.88 | HTR1A (0.37) | ALDH1A1HTR7 | |
| SCHEMBL5140412 | 0.79 | AQP1 (0.37) | — | |
| SCHEMBL4596946 | 0.78 | BRD4 (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL4233581 | 0.77 | PRKAB2 (0.46) | SIRT2ALDH1A1MAPK1HTR7 | |
| SCHEMBL4596943 | 0.77 | HTR7 (0.35) | ALDH1A1MAPK1HTR7 | |
| SCHEMBL4971360 | 0.74 | AQP1 (0.35) | DRD2HTR7 | |
| SCHEMBL5606147 | 0.71 | LMNA (0.35) | ALDH1A1MAPK1HTR7 | |
| SCHEMBL4969988 | 0.70 | AQP1 (0.46) | — | |
| SCHEMBL4791170 | 0.69 | AQP1 (0.39) | SIRT2ALDH1A1MAPK1 | |
| SCHEMBL4863731 | 0.69 | NUDT1 (0.39) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871356-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116170-A1 | DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | claimed |