Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4971834 | 0.96 | CD274 (0.50) | ALDH1A1L3MBTL1TSHRCD274HPGDS | |
| SCHEMBL4971152 | 0.92 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1TSHRHTTSMN1; SMN2 | |
| SCHEMBL4973225 | 0.85 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2472834 | 0.84 | L3MBTL1 (0.52) | ALDH1A1L3MBTL1TSHRHTTSMN1; SMN2 | |
| SCHEMBL4972400 | 0.82 | GABRA5 (0.58) | MAPK14 | |
| SCHEMBL4974708 | 0.81 | GABRA5 (0.43) | — | |
| SCHEMBL4971020 | 0.81 | GABRA5 (0.55) | HPGDSMAPK14 | |
| SCHEMBL2471775 | 0.79 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1TSHRCD274HPGDS | |
| SCHEMBL4971397 | 0.79 | GABRA5 (0.51) | HPGDS | |
| SCHEMBL4970569 | 0.79 | GABRA5 (0.51) | HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | claimed |
| EP-1968973-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074078-A2 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-05 | — | — | WO | disclosed |