Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970261 | 0.84 | KDM4E (0.42) | MEN1ALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL4967660 | 0.83 | KDM4E (0.46) | MEN1ALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL4972772 | 0.81 | HTR6 (0.39) | ALDH1A1KMT2AHSD17B10ACHEHTR6 | |
| SCHEMBL4971283 | 0.80 | HTR6 (0.39) | MEN1ALDH1A1KMT2AACHETP53 | |
| SCHEMBL5513518 | 0.76 | MEN1 (0.45) | MEN1ALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL4970199 | 0.69 | CYP11B1 (0.37) | MEN1ALDH1A1KMT2AHTR6 | |
| SCHEMBL4968337 | 0.68 | MAPT (0.44) | MEN1ALDH1A1KMT2AHPGDHSD17B10 | |
| SCHEMBL16484323 | 0.68 | KDM4E (0.50) | MEN1ALDH1A1KMT2AL3MBTL1LMNA | |
| SCHEMBL4968898 | 0.67 | MEN1 (0.44) | MEN1ALDH1A1KMT2AHSD17B10TP53 | |
| SCHEMBL4969062 | 0.67 | KDM4E (0.43) | MEN1ALDH1A1KMT2AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654228-B1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | claimed |