SCHEMBL497733

SCHEMBL497733

FC(F)(F)c1cc(P(Cl)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc(C(F)(F)F)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.41
IDO1 P14902 2/20 0.37
TSHR P16473 3/20 0.34
ALDH1A1 P00352 2/20 0.34
CYP3A4 P08684 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
HIF1A Q16665 1/20 0.34
TXNRD1 Q16881 1/20 0.34
TXNRD3 Q86VQ6 1/20 0.34
TXNRD2 Q9NNW7 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
LMNA P02545 1/20 0.33
ADRB1 P08588 1/20 0.33
MAPT P10636 1/20 0.32
RAPGEF4 Q8WZA2 1/20 0.32
ITGB3 P05106 1/20 0.32
ITGAV P06756 1/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16351489 0.89 RAPGEF4 (0.43) CES2IDO1MAPTRAPGEF4RXRA
SCHEMBL2879502 0.84 CES2 (0.41) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL17448589 0.82 CES2 (0.39) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL383565 0.78 CES2 (0.44) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL3025058 0.77 CES2 (0.48) CES2IDO1TSHRALDH1A1TDP1
SCHEMBL440959 0.76 CES2 (0.58) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL16861287 0.76 CES2 (0.42) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL10271930 0.76 CES2 (0.42) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL16823330 0.76 CES2 (0.42) CES2IDO1TSHRALDH1A1CYP3A4
SCHEMBL15329899 0.76 CES2 (0.42) CES2IDO1TSHRALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1598053-B1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres OREAL (FR) 2006-12-20 EP claimed
EP-1598053-A1 Use of a composition containing at least one phosphine as majority reducing agent to remove the artificial colour of keratinic fibres L'OREAL (FR) 2005-11-23 EP claimed
US-20050251928-A1 Method for stripping artificial color from keratin fibers L'OREAL (FR) 2005-11-17 US claimed
US-20260116900-A1 PHOSPHINE-PHENOL TRANSITION METAL COMPLEX, PREPARATION METHOD THEREFOR, AND USE THEREOF CHINA PETROLEUM & CHEM CORP (CN) 2026-04-30 US disclosed
EP-4707283-A1 TETRAHYDRONAPHTHOL-PHOSPHINE PRE-TRANSITION METAL COMPLEX, AND PREPARATION METHOD THEREFOR AND USE THEREOF China Petroleum & Chemical Corporation (CN) 2026-03-11 EP disclosed
US-20250368598-A1 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES BHATTACHARYA SHRABANTI (US) 2025-12-04 US disclosed
EP-4603493-A1 PHOSPHINE-PHENOL TRANSITION METAL COMPLEX, PREPARATION METHOD THEREFOR, AND USE THEREOF CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2025-08-20 EP disclosed
CN-119998255-A Catalytic carboxycarbonylation of olefins to form anhydrides 北卡罗来纳大学教堂山分校 2025-05-13 CN disclosed
EP-4543841-A2 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES The University of North Carolina at Chapel Hill (US) 2025-04-30 EP disclosed
CN-119661749-A Coordination precipitation polymerization process for olefin polymerization and polyolefin 中国石油化工股份有限公司 2025-03-21 CN disclosed
CN-119661750-A Coordination precipitation polymerization process for olefin polymerization and polyolefin 中国石油化工股份有限公司 2025-03-21 CN disclosed
US-5574171-A OF VINYL COMPOUNDS TO PRODUCE 2-SUBSTITUTED 1-PROPANALS, A METAL COMPLEX OF A DIPHOSPHINOGLUCOPYRANOSIDE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-11-12 US disclosed
US-5510470-A CONTAINS A DIDEOXYSACCHARIDE; USED WITH ZERO VALENT NICKEL AS A CATALYST FOR ENANTIOSELECTIVE HYDROCYANATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-04-23 US disclosed
US-5510507-A COORDINATION CATALYSTS; EFFICIENT ENANTIOSELECTIVITY E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-04-23 US disclosed
US-5484902-A HYDROCYANATION OF VINYL AROMATICS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-01-16 US disclosed
US-5481006-A PREPARATION OF INTERMEDIATES FOR PHARMACEUTICALS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-01-02 US disclosed
US-5475146-A Reacting vinyl compound with carbon monoxide and hydrogen in presence of catalyst containing cobalt, rhodium, platinum and/or iridium and chiral carbohydrate phosphorus ligand substituted with electron withdrawing groups E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-12-12 US disclosed
WO-1995006627-A1 ENANTIOSELECTIVE HYDROFORMYLATION E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-09 WO disclosed
US-5312957-A 2-/6-Methoxy-2-naphthalene/propionitrile E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-05-17 US disclosed
US-5175335-A Reacting vinyl aryl compounds with a source of hydrocyanic acid in presence of nickle zero valent compound and nonracemic bidentate organophosphorus ligand E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250368598-A1 CATALYTIC CARBOXYCARBONYLATION OF ALKENES TO FORM ANHYDRIDES CA4, CA12, CA14 CES2 654/4885IDO1 851/4885TSHR 4615/4885
US-20260116900-A1 PHOSPHINE-PHENOL TRANSITION METAL COMPLEX, PREPARATION METHOD THEREFOR, AND USE THEREOF WEE1, WEE2, CYP4F11 CES2 3464/4885IDO1 691/4885TSHR 1985/4885
US-20050251928-A1 Method for stripping artificial color from keratin fibers KRT18, DSG1, JUP CES2 4564/4885IDO1 3857/4885TSHR 4245/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.