Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143430 | 0.82 | CYP3A4 (0.39) | MAPTL3MBTL1CYP3A4CNR1POLB | |
| SCHEMBL498094 | 0.80 | ALDH1A1 (0.36) | MAPTL3MBTL1CNR1POLBMEN1 | |
| Formaldehyde SCHEMBL8154211 | 0.80 | CYP3A4 (0.38) | MAPTL3MBTL1CYP3A4POLBKMT2A | |
| Bromide SCHEMBL27540325 | 0.78 | CYP3A4 (0.37) | CYP3A4POLBGAALMNANPSR1 | |
| SCHEMBL25419774 | 0.77 | CYP3A4 (0.35) | CYP3A4POLBGAALMNANPSR1 | |
| SCHEMBL497275 | 0.77 | CYP3A4 (0.35) | L3MBTL1CYP3A4POLBMEN1KMT2A | |
| SCHEMBL28402591 | 0.74 | — | — | |
| SCHEMBL10653236 | 0.74 | — | — | |
| SCHEMBL5955059 | 0.73 | ACHE (0.30) | — | |
| SCHEMBL18814744 | 0.71 | CRBN (0.35) | MEN1KMT2ACRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106214-B2 | 2-imino-4-(thio) oxo-5-polycyclovinylazolines for use as PI3 kinase inhibitors | MERCK SERONO SA (CH) | 2012-01-31 | — | — | US | disclosed |
| US-7919630-B2 | Synthesis of imidazole 2-thiones via thiohydantoins | ALLERGAN, INC. (US) | 2011-04-05 | — | — | US | disclosed |
| EP-1648452-B1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | MERCK SERONO SA (CH) | 2009-07-22 | — | — | EP | disclosed |
| US-7435713-B2 | Compositions and methods for removal of incidental soils from fabric articles via soil modification | THE PROCTER & GAMBLE COMPANY (US) | 2008-10-14 | — | — | US | disclosed |
| US-20070203344-A1 | SYNTHESIS OF IMIDAZOLE 2-THIONES VIA THIOHYDANTOINS | ALLERGAN, INC. | 2007-08-30 | — | — | US | disclosed |
| WO-2007041048-A2 | SYNTHESIS OF IMIDAZOLE-2-THIONES VIA THIOHYDANTOINS | ALLERGAN, INC. (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-01-25 | — | — | US | disclosed |
| EP-1451403-B1 | COMPOSITIONS AND METHODS FOR REMOVAL OF INCIDENTAL SOILS FROM FABRIC ARTICLES VIA SOIL MODIFICATION | PROCTER & GAMBLE (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-1648452-A1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2006-04-26 | — | — | EP | disclosed |
| US-20050137108-A1 | Compositions and methods for removal of incidental soils from fabric articles via soil modification | THE PROCTER & GAMBLE COMPANY | 2005-06-23 | — | — | US | disclosed |
| WO-2005011686-A1 | 2-IMINO-4-(THIO) OXO-5-POLY CYCLOVINYLAZOLINES FOR USE AS P13 KINASE IHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2005-02-10 | — | — | WO | disclosed |
| EP-1451403-A1 | COMPOSITIONS AND METHODS FOR REMOVAL OF INCIDENTAL SOILS FROM FABRIC ARTICLES VIA SOIL MODIFICATION | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003050344-A1 | COMPOSITIONS AND METHODS FOR REMOVAL OF INCIDENTAL SOILS FROM FABRIC ARTICLES VIA SOIL MODIFICATION | THE PROCTER & GAMBLE COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
| US-5717075-A | FORMED BY REACTING MEMBRANE THAT HAS BOUND CARBOXYLIC ACID GROUPS WITH 2-ETHYL-5'-PHENYLISOXAZOLIUM SULFONATE | THE PERKIN-ELMER CORPORATION (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0677058-A4 | SUPPORT AND METHOD FOR IMMOBILIZING POLYPEPTIDES. | APPLIED BIOSYSTEMS (US) | 1997-09-24 | — | — | EP | disclosed |
| US-5602207-A | A POLYVINYLIDENE FLUORIDE MEMBRANE HAVING SURFACE-ATTACHED ENOL ESTER GROUPS AND SURFACE ATTACHED SULFONATE GROUPS | THE PERKIN-ELMER CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0677058-A1 | SUPPORT AND METHOD FOR IMMOBILIZING POLYPEPTIDES | THE PERKIN-ELMER CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994015948-A1 | SUPPORT AND METHOD FOR IMMOBILIZING POLYPEPTIDES | APPLIED BIOSYSTEMS, INC. (US) | 1994-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021447-A1 | 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors | PI4K2B, PI4KA, PTK2B | MAPT 3683/4885L3MBTL1 1438/4885CYP3A4 1956/4885 |
| US-20070203344-A1 | SYNTHESIS OF IMIDAZOLE 2-THIONES VIA THIOHYDANTOINS | TPMT, NISCH, IMPDH2 | MAPT 1647/4885L3MBTL1 3762/4885CYP3A4 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.