Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of P-Xylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | LPL | P06858 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL11770184 | 0.89 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL11772917 | 0.89 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL771 | 0.89 | — | — | |
| P-Xylene SCHEMBL460348 | 0.89 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL11003481 | 0.84 | — | — | |
| P-Xylene SCHEMBL1508153 | 0.84 | ACHE (0.89) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL21270023 | 0.84 | — | — | |
| P-Xylene SCHEMBL20873607 | 0.84 | — | — | |
| P-Xylene SCHEMBL461064 | 0.84 | ACHE (0.89) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL3847044 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8105431-B2 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2012-01-31 | — | — | US | disclosed |
| EP-2184328-B1 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same | ORIENT CHEMICAL IND (JP) | 2011-04-27 | — | — | EP | disclosed |
| EP-2184328-A2 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same | Orient Chemical Industries, Ltd. (JP) | 2010-05-12 | — | — | EP | disclosed |
| US-20100036134-A1 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same | ORIENT CHEMICAL INDUSTRIES, LTD. (JP) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100036134-A1 | Subphthalocyanine derivative having phosphorus derivative as axially substituted group, method for manufacturing the same and optical film using the same | PHLPP1, PHLPP2, PROX1 | ACHE 2685/4885TDP1 1636/4885ALDH1A1 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.