Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of P-Xylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.89 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | LPL | P06858 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.47 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.47 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.47 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL18229935 | 1.00 | — | — | |
| P-Xylene SCHEMBL28067071 | 1.00 | ACHE (0.89) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL10657290 | 0.95 | ACHE (0.80) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL11772917 | 0.94 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL771 | 0.94 | — | — | |
| P-Xylene SCHEMBL460348 | 0.94 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL11770184 | 0.94 | ACHE (1.00) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL29093798 | 0.91 | ACHE (0.73) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL9119408 | 0.89 | ACHE (0.89) | ACHETDP1ALDH1A1CA2CA1 | |
| P-Xylene SCHEMBL3847044 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117427205-A | Modified medical adhesive composition and preparation method and application thereof | 北京康派特医疗器械有限公司 | 2024-01-23 | — | — | CN | claimed |
| CN-117427204-A | Modified medical adhesive and preparation method and application thereof | 北京康派特医疗器械有限公司 | 2024-01-23 | — | — | CN | claimed |
| CN-111116928-B | Supermolecule hyperbranched polymer using double drug molecules as basic units and preparation method thereof | 西北工业大学 | 2021-11-12 | — | — | CN | claimed |
| CN-113234076-A | Preparation method of doxofylline | 湖北午时药业股份有限公司 | 2021-08-10 | — | — | CN | claimed |
| CN-113117723-A | Composite catalyst for synthesizing p-phenyl dimethyl ether and preparation method and industrial application thereof | 陕西煤业化工技术研究院有限责任公司 | 2021-07-16 | — | — | CN | claimed |
| CN-113105490-A | Method for synthesizing aryl-beta-diketone boron difluoride compound by one-pot method | 河南省科学院高新技术研究中心 | 2021-07-13 | — | — | CN | claimed |
| CN-110407663-B | Dechlorination method of chlorine-containing aromatic compound | 厦门大学 | 2021-01-26 | — | — | CN | claimed |
| CN-111517314-A | Graphene testing method | 中国科学院重庆绿色智能技术研究院 | 2020-08-11 | — | — | CN | claimed |
| CN-111289677-A | Method for measuring spicy components in main stream smoke of cigarette | 中国烟草总公司郑州烟草研究院 | 2020-06-16 | — | — | CN | claimed |
| CN-111116928-A | Supermolecule hyperbranched polymer using double drug molecules as basic units and preparation method thereof | 西北工业大学 | 2020-05-08 | — | — | CN | claimed |
| CN-111073021-A | Method for preparing oxygen-enriched super-crosslinked resin based on Friedel-crafts alkylation reaction and application of oxygen-enriched super-crosslinked resin | 中南大学 | 2020-04-28 | — | — | CN | claimed |
| CN-108238904-A | The synthetic method of para-amiunomethylbenzoic acid pharmaceutical intermediate p-methylbenzoic acid | 成都千叶龙华石油工程技术咨询有限公司 | 2018-07-03 | — | — | CN | claimed |
| CN-110972536-B | Preparation method of ablation-resistant phenolic resin for RTM (resin transfer molding) and phenolic resin composition | 华东理工大学 | 2014-02-12 | — | — | CN | claimed |
| US-20130190501-A1 | PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF | SYMED LABS LIMITED (IN) | 2013-07-25 | — | — | US | claimed |
| WO-2013027225-A1 | PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE | SYMED LABS LIMITED (IN) | 2013-02-28 | — | — | WO | claimed |
| WO-2012032532-A1 | \"PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF\ | SYMED LABS LIMITED (IN) | 2012-03-15 | — | — | WO | claimed |
| CN-117700308-B | Synthesis method of terephthalyl ether | 中国科学院大连化学物理研究所 | 2026-05-19 | — | — | CN | disclosed |
| CN-121298968-A | Method for detecting terephthalyl ether in honey and application of method in identification of nectar | 秦皇岛海关技术中心 | 2026-01-09 | — | — | CN | disclosed |
| US-4816336-A | AND QUATERNARY AMMONIUM ETHOXYSULFATE AND POLYOXYETHYLENE ETHER MODIFIED WITH FATTY ACID | HOECHST CELANESE CORPORATION (US) | 1989-03-28 | — | — | US | disclosed |
| CN-87101646-A | Use a kind of isomerization/transalkylation section of economic benefits and social benefits and produce dimethylbenzene | — | 1988-08-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190501-A1 | PROCESSES FOR THE PREPARATION OF 4'-[3-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINO]PROPOXY]-3'-METHOXYACETOPHENONE AND INTERMEDIATES THEREOF | CYP4B1, CYP4X1, CYP3A4 | ACHE 2911/4885TDP1 3250/4885ALDH1A1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.