Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.59 |
| ▸ | HTR3B | O95264 | 3/20 | 0.59 |
| ▸ | HTR3A | P46098 | 3/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | HTR5A | P47898 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17640683 | 0.86 | MAPT (0.52) | ALDH1A1TSHRHSD17B10ABL1TP53 | |
| SCHEMBL24779093 | 0.84 | NPC1 (0.51) | ALDH1A1TSHRHSD17B10ABL1TP53 | |
| SCHEMBL232986 | 0.84 | ALDH1A1 (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6094124 | 0.84 | ALDH1A1 (0.65) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL17631586 | 0.82 | PRKDC (0.58) | ALDH1A1TSHRHSD17B10TP53HTT | |
| SCHEMBL3453744 | 0.81 | ADRB1 (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4976412 | 0.81 | LMNA (0.52) | ALDH1A1USP2TSHRHSD17B10HTT | |
| SCHEMBL4979464 | 0.80 | BRD4 (0.47) | ALDH1A1USP2ABL1 | |
| Hydrochloric Acid SCHEMBL4713477 | 0.80 | ADRB1 (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4979546 | 0.79 | HTR3A (0.52) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7341709-B2 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles | REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 2008-03-11 | — | — | US | disclosed |
| US-20070053831-A1 | Methods for binding agents to b-amyloid plaques | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-08 | — | — | US | disclosed |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2004-04-15 | — | — | US | disclosed |
| US-6660530-B2 | Diagnosis of Alzheimer's disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-12-09 | — | — | US | disclosed |
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-21 | — | — | US | disclosed |
| US-6274119-B1 | LABELING .BETA.-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES IN VIVO AND IN VITRO, COMPRISES CONTACTING RADIOLABELED AMINONAPTHALENE DERIVATIVE WITH MAMMALIAN TISSUE | THE REGENTS OF THE UNIV. OF CALIFORNIA | 2001-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | OXSR1, MSR1, CBR1 | HTR3E 706/4885HTR3B 316/4885HTR3A 836/4885 |
| US-20070053831-A1 | Methods for binding agents to b-amyloid plaques | APBA1, CLTB, FABP7 | HTR3E 2443/4885HTR3B 1485/4885HTR3A 2262/4885 |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | CBR1, CBR3, MSR1 | HTR3E 770/4885HTR3B 462/4885HTR3A 1032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.