Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.52 |
| ▸ | HTR3B | O95264 | 4/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977907 | 0.79 | HTR3E (0.59) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4975218 | 0.77 | GPR119 (0.49) | MAPTALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL14527673 | 0.72 | MAPT (0.55) | MAPTAPPSNCAALDH1A1HSD17B10 | |
| SCHEMBL4975214 | 0.71 | SLC6A9 (0.38) | MAPTAPPSNCATSHRUSP2 | |
| SCHEMBL28836584 | 0.71 | MAPT (0.49) | MAPTTSHRUSP2ALDH1A1HSD17B10 | |
| SCHEMBL15534306 | 0.70 | HTR3A (0.69) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL15596831 | 0.70 | MAPT (0.54) | MAPTAPPSNCAALDH1A1HSD17B10 | |
| SCHEMBL3138664 | 0.70 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL30870394 | 0.70 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL21477129 | 0.69 | MAPT (0.52) | HTR1ADRD3MAPTAPPSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7341709-B2 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles | REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 2008-03-11 | — | — | US | disclosed |
| US-7341709-B2 | Compositions for labeling β-amyloid plaques and neurofibrillary tangles | REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 2008-03-11 | — | — | US | disclosed |
| EP-1624900-A4 | METHODS FOR BINDING AGENTS TO BETA-AMYLOID PLAQUES | UNIV CALIFORNIA (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20070053831-A1 | Methods for binding agents to b-amyloid plaques | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-08 | — | — | US | disclosed |
| US-20070053831-A1 | Methods for binding agents to b-amyloid plaques | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-03-08 | — | — | US | disclosed |
| EP-1624900-A2 | METHODS FOR BINDING AGENTS TO BETA-AMYLOID PLAQUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005040337-A2 | METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2004-04-15 | — | — | US | disclosed |
| US-6660530-B2 | Diagnosis of Alzheimer's disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-12-09 | — | — | US | disclosed |
| EP-1105163-A4 | METHODS FOR LABELING BETA-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | UNIV CALIFORNIA (US) | 2003-05-02 | — | — | EP | disclosed |
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-02-21 | — | — | US | disclosed |
| US-6274119-B1 | LABELING .BETA.-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES IN VIVO AND IN VITRO, COMPRISES CONTACTING RADIOLABELED AMINONAPTHALENE DERIVATIVE WITH MAMMALIAN TISSUE | THE REGENTS OF THE UNIV. OF CALIFORNIA | 2001-08-14 | — | — | US | disclosed |
| EP-1105163-A1 | METHODS FOR LABELING BETA-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010614-A1 | METHODS FOR LABELING β-AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020022002-A1 | Methods for labeling beta-amyloid plaques and neurofibrillary tangles | OXSR1, MSR1, CBR1 | HTR3A 836/4885HTR3E 706/4885HTR3B 316/4885 |
| US-20070053831-A1 | Methods for binding agents to b-amyloid plaques | APBA1, CLTB, FABP7 | HTR3A 2262/4885HTR3E 2443/4885HTR3B 1485/4885 |
| US-20040072371-A1 | Compositions for labeling beta-amyloid plaques and neurofibrillary tangles | CBR1, CBR3, MSR1 | HTR3A 1032/4885HTR3E 770/4885HTR3B 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.