Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29139810 | 0.84 | FGFR1 (0.47) | XDHDHFRHCAR1FGFR1RAB9A | |
| SCHEMBL17052498 | 0.81 | HCAR1 (0.43) | XDHHCAR1RPS6KA3MAPK6FGFR1 | |
| SCHEMBL17802582 | 0.80 | CFTR (0.54) | RPS6KA3FGFR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2409198 | 0.78 | HDAC6 (0.52) | RPS6KA3FGFR1KDM4EALDH1A1HDAC6 | |
| Phenol SCHEMBL28142595 | 0.78 | FGFR1 (0.49) | RPS6KA3FGFR1HTTESR1ESR2 | |
| SCHEMBL426847 | 0.76 | HCAR1 (0.48) | XDHDHFRHCAR1RAB9ASMN1; SMN2 | |
| SCHEMBL30684918 | 0.76 | MAPKAPK2 (0.57) | DHFR | |
| SCHEMBL27745688 | 0.76 | PI4KA (0.52) | HCAR1KDM4EHTTHDAC6MAPT | |
| SCHEMBL27870413 | 0.75 | XDH (0.58) | XDHDHFRGRM1 | |
| SCHEMBL6945092 | 0.75 | HDAC6 (0.64) | SMN1; SMN2KDM4EALDH1A1HTTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454325-A | 8-heteroarylpurine MNK2 inhibitors for the treatment of metabolic disorders | PHARMACOPEIA INC (US) | 2009-06-10 | — | — | CN | claimed |
| EP-1991547-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2008-11-19 | — | — | EP | claimed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | claimed |
| CN-101454325-A | 8-heteroarylpurine MNK2 inhibitors for the treatment of metabolic disorders | PHARMACOPEIA INC (US) | 2009-06-10 | — | — | CN | disclosed |
| EP-1991547-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007104053-A2 | 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS | PHARMACOPEIA, INC. (US) | 2007-09-13 | — | — | WO | disclosed |