Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 14/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | CTSL | P07711 | 6/20 | 0.42 |
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27537266 | 1.00 | CTSB (0.44) | CTSBCTSSCTSLCTSKSLC7A5 | |
| SCHEMBL4978214 | 0.89 | CTSB (0.48) | CTSBCTSSCTSLCTSKPPARA | |
| SCHEMBL4981307 | 0.86 | SLC7A5 (0.44) | CTSSSLC7A5PPARAPPARG | |
| SCHEMBL27546125 | 0.86 | SLC7A5 (0.44) | CTSSSLC7A5PPARAPPARG | |
| SCHEMBL4981310 | 0.81 | PPARA (0.49) | CTSBCTSSCTSLCTSKSLC7A5 | |
| SCHEMBL4979372 | 0.81 | PPARA (0.60) | CTSBCTSSCTSKSLC7A5PPARA | |
| SCHEMBL27519734 | 0.81 | PPARA (0.60) | CTSBCTSSCTSKSLC7A5PPARA | |
| SCHEMBL6218326 | 0.77 | CTSB (0.47) | CTSBCTSSCTSLCTSKPPARA | |
| SCHEMBL6213718 | 0.77 | CTSB (0.47) | CTSBCTSSCTSLCTSKPPARA | |
| SCHEMBL4982270 | 0.77 | CTSB (0.58) | CTSBCTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | CTSB 5/4885CTSS 3/4885CTSL 1/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | CTSB 5/4885CTSS 3/4885CTSL 2/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | CTSB 3/4885CTSS 2/4885CTSL 1/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | CTSB 3/4885CTSS 2/4885CTSL 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.