Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.47 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ACLY | P53396 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205612 | 1.00 | HTR6 (0.47) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4520356 | 0.83 | HTR6 (0.52) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4518573 | 0.82 | HTR6 (0.69) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4210810 | 0.82 | DRD2 (0.42) | HTR6QRFPRCYP3A4DRD2HTR1A | |
| SCHEMBL4209393 | 0.81 | HTR6 (0.67) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4199371 | 0.78 | GHSR (0.44) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4513802 | 0.78 | HTR6 (0.53) | HTR6QRFPRALDH1A1KMT2ALMNA | |
| SCHEMBL4519556 | 0.76 | HTR6 (0.48) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4527076 | 0.76 | THRB (0.56) | HTR6QRFPRALDH1A1KMT2AMEN1 | |
| SCHEMBL4210918 | 0.75 | ALDH1A1 (0.54) | HTR6ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | claimed |