Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4980305 | 0.85 | KCNA5 (0.39) | KCNA5KCNH2NPC1RAB9ACYP11B1 | |
| SCHEMBL4979253 | 0.85 | CYP11B2 (0.46) | KCNA5KCNH2CYP11B1CYP11B2PDE5A | |
| SCHEMBL4979558 | 0.82 | CYP11B2 (0.48) | KCNA5KCNH2CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL4977530 | 0.82 | CYP11B1 (0.48) | KCNA5KCNH2CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL4977669 | 0.81 | CYP11B1 (0.54) | KCNA5KCNH2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4977077 | 0.81 | CYP11B1 (0.53) | MAPTNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4982009 | 0.80 | MKNK1 (0.47) | KCNA5KCNH2TSHRCYP11B1CYP11B2 | |
| SCHEMBL4975675 | 0.80 | MKNK1 (0.47) | KCNA5NPC1RAB9ACYP11B1CYP11B2 | |
| SCHEMBL4974371 | 0.79 | KCNA5 (0.50) | KCNA5KCNH2MAPTTP53SMN1; SMN2 | |
| SCHEMBL4975470 | 0.78 | KCNA5 (0.51) | KCNA5KCNH2MAPTKCNN4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |