Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.68 |
| ▸ | PPARG | P37231 | 4/20 | 0.68 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | CDC25B | P30305 | 4/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.46 |
| ▸ | CDC25A | P30304 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521040 | 1.00 | PPARA (0.68) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL4982693 | 0.90 | PPARA (0.55) | PPARAPPARGCTSSACESLC7A5 | |
| SCHEMBL27519734 | 0.87 | PPARA (0.60) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL4979372 | 0.87 | PPARA (0.60) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL1196766 | 0.86 | ACE (0.61) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL1196768 | 0.86 | ACE (0.61) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL14058124 | 0.86 | PPARA (0.69) | PPARAPPARGCTSSACEKLK7 | |
| SCHEMBL14058126 | 0.86 | PPARA (0.69) | PPARAPPARGCTSSACEKLK7 | |
| SCHEMBL14056985 | 0.85 | PPARA (0.71) | PPARAPPARGCTSSACEPPARD | |
| SCHEMBL14056987 | 0.85 | PPARA (0.71) | PPARAPPARGCTSSACEPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027060-A1 | DIPEPTIDE NITRILES | ALTMANN EVA | 2008-01-31 | — | — | US | disclosed |
| US-20060235220-A1 | Dipeptide nitriles | MISSBACH MARTIN | 2006-10-19 | — | — | US | disclosed |
| CN-1273444-C | Dipeptide nitriles | NOVARTIS AG (CH) | 2006-09-06 | — | — | CN | disclosed |
| US-20040110806-A1 | Dipeptide derivatives | ALTMANN EVA (CH) | 2004-06-10 | — | — | US | disclosed |
| US-20040029814-A1 | Dipeptide nitriles | ALTMANN EVA (CH) | 2004-02-12 | — | — | US | disclosed |
| US-6353017-B1 | INHIBITORS OF CATHESPINS USING DIPEPTIDE NITRILES AS ANTIINFLAMMATORY AGENTS AND ANTIARTHRITIC AGENTS | NOVARTIS AG (CH) | 2002-03-05 | — | — | US | disclosed |
| CN-1278244-A | Dipeptide nitriles | NOVARTIS AG (CH) | 2000-12-27 | — | — | CN | disclosed |
| EP-1028942-A2 | DIPEPTIDE NITRILES | Novartis AG (CH) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024460-A2 | DIPEPTIDE NITRILES | NOVARTIS AG (CH) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110806-A1 | Dipeptide derivatives | CTSL, CTSZ, CTSS | PPARA 3269/4885PPARG 2990/4885CTSS 3/4885 |
| US-20040029814-A1 | Dipeptide nitriles | NOS1, CTSL, CTSS | PPARA 3269/4885PPARG 3093/4885CTSS 3/4885 |
| US-20060235220-A1 | Dipeptide nitriles | CTSL, CTSS, CTSB | PPARA 3152/4885PPARG 2902/4885CTSS 2/4885 |
| US-20080027060-A1 | DIPEPTIDE NITRILES | CTSL, CTSS, CTSB | PPARA 3152/4885PPARG 2902/4885CTSS 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.