Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211836 | 0.98 | TSHR (0.39) | TSHRGABRR1GABRR2BLMLMNA | |
| SCHEMBL6061868 | 0.96 | TSHR (0.38) | TSHRGABRR1GABRR2BLMLMNA | |
| Ammonia Solution, Strong SCHEMBL3280212 | 0.96 | TSHR (0.38) | TSHRGABRR1GABRR2BLMLMNA | |
| Acrylic Acid SCHEMBL6444076 | 0.94 | LMNA (0.40) | TSHRGABRR1GABRR2BLMLMNA | |
| Vinyl Chloride SCHEMBL259499 | 0.92 | GABRR1 (0.35) | TSHRGABRR1GABRR2BLMLMNA | |
| Vinyl Chloride SCHEMBL6562575 | 0.92 | GABRR1 (0.35) | TSHRGABRR1GABRR2BLMLMNA | |
| Acetic Acid SCHEMBL6563939 | 0.92 | GABRR1 (0.35) | TSHRGABRR1GABRR2BLMLMNA | |
| Acrylic Acid SCHEMBL6562656 | 0.89 | LMNA (0.36) | TSHRGABRR1GABRR2BLMLMNA | |
| Methacrylic Acid SCHEMBL4684697 | 0.87 | GABRR1 (0.32) | TSHRGABRR1GABRR2BLMLMNA | |
| Acrylic Acid Methyl Ester SCHEMBL4672549 | 0.84 | HCAR2 (0.41) | TSHRGABRR1GABRR2BLMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280880-B1 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | PROCTER & GAMBLE (US) | 2008-10-29 | — | — | EP | disclosed |
| US-6740633-B2 | Polyelectrolyte complexes and a method for production thereof | BASF AKTIENGESELLSCHAFT (DE) | 2004-05-25 | — | — | US | disclosed |
| US-6596678-B2 | Polyelectrolyte complex of cationic adducts or polymers of (poly)amines crosslinked with epihalohydrins, and a polyanionic polymer such as polysodium acrylate | THE PROCTER & GAMBLE CO. | 2003-07-22 | — | — | US | disclosed |
| US-20030078185-A1 | Polyelectrolyte complexes and a method for production thereof | BASF AKTIENGESELLSCHAFT (DE) | 2003-04-24 | — | — | US | disclosed |
| EP-1280880-A2 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 2003-02-05 | — | — | EP | disclosed |
| US-20010056058-A1 | Laundry detergent compositions containing a polymer for fabric appearance improvement | THE PROCTER & GAMBLE COMPANY | 2001-12-27 | — | — | US | disclosed |
| WO-2001085891-A2 | LAUNDRY DETERGENT COMPOSITIONS CONTAINING A POLYMER | THE PROCTER & GAMBLE COMPANY (US) | 2001-11-15 | — | — | WO | disclosed |
| US-5126411-A | For coatings, films, fibers, adhesives | HOECHST AG (DE) | 1992-06-30 | — | — | US | disclosed |
| US-5089570-A | Protective colloids | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |