Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16651825 | 0.87 | ALDH1A1 (0.51) | LMNAPDE4DTP53ALDH1A1KDM4E | |
| SCHEMBL6422295 | 0.86 | KMT2A (0.65) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL19507067 | 0.84 | LMNA (0.52) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL6415151 | 0.83 | LMNA (0.56) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL19475586 | 0.83 | ALDH1A1 (0.59) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL22896894 | 0.83 | LMNA (0.56) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL14132421 | 0.82 | LMNA (0.70) | LMNATP53ALDH1A1KDM4EPOLB | |
| SCHEMBL16112468 | 0.82 | LMNA (0.73) | LMNAPDE4DALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6415169 | 0.82 | LMNA (0.55) | LMNAPDE4DTP53ALOX12ALDH1A1 | |
| SCHEMBL19507068 | 0.82 | CA9 (0.54) | LMNAPDE4DTP53ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
| EP-1417175-B1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | DU PONT (US) | 2013-07-24 | — | — | EP | disclosed |
| US-7402676-B2 | Substituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-07-22 | — | — | US | disclosed |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2007-08-30 | — | — | US | disclosed |
| US-7227025-B2 | Substituted dihydro 3-halo-1H-pyrazole-T-carboxylates, their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6965032-B2 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates and their preparation and use | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-11-15 | — | — | US | disclosed |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | FMC CORPORATION | 2005-11-03 | — | — | US | disclosed |
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | FMC CORPORATION | 2004-10-07 | — | — | US | disclosed |
| EP-1417175-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES, THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003016283-A1 | SUBSTITUTED DIHYDRO 3-HALO-1H-PYRAZOLE-5-CARBOXYLATES THEIR PREPARATION AND USE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198987-A1 | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, CYP2F1 | LMNA 2750/4885PDE4D 1404/4885TP53 3326/4885 |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LMNA 1415/4885PDE4D 1079/4885TP53 1804/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | LMNA 1105/4885PDE4D 1041/4885TP53 1368/4885 |
| US-20070203342-A1 | Subtituted dihydro 3-halo-1H-pyrazole-5-carboxylates their preparation and use | CBR3, CBR1, DHRS9 | LMNA 2609/4885PDE4D 476/4885TP53 2154/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | LMNA 1415/4885PDE4D 1079/4885TP53 1804/4885 |
| US-20050245580-A1 | Halogenation and oxidation of a 5-carboxyl-3-oxo-1-aryl-substituted-1H-pyrazolidine | CBR3, CBR1, CYP2F1 | LMNA 3053/4885PDE4D 1440/4885TP53 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.