Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828886 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2829309 | 0.88 | PIM1 (0.48) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2827089 | 0.87 | LMNA (0.46) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2830390 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL2829272 | 0.86 | KMT2A (0.52) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2853086 | 0.86 | ALDH1A1 (0.44) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2827476 | 0.83 | KMT2A (0.46) | SMN1; SMN2HTTNPC1RAB9AALDH1A1 | |
| SCHEMBL2831568 | 0.83 | POLB (0.38) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2829280 | 0.82 | PIM1 (0.46) | SMN1; SMN2HTTNPC1RAB9AKDM4E | |
| SCHEMBL2829708 | 0.82 | KMT2A (0.46) | SMN1; SMN2HTTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388025-B2 | 3-aryl-isoxazole-4-carbonyl-benzofuran derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-20070105922-A1 | 3-aryl-isoxazole-4-carbonyl-indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105922-A1 | 3-aryl-isoxazole-4-carbonyl-indole derivatives | GABRA5, GABRA4, GABRA3 | SMN1; SMN2 2521/4885HTT 1743/4885NPC1 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.