SCHEMBL498723

SCHEMBL498723

NC=CCc1cn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RY6 Q15077 13/20 0.66
P2RY2 P41231 13/20 0.66
DNPH1 O43598 1/20 0.62
P2RY4 P51582 6/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL498724 1.00 P2RY6 (0.66) P2RY6P2RY2DNPH1P2RY4
Cyanide SCHEMBL29185235 0.97 P2RY6 (0.63) P2RY6P2RY2DNPH1P2RY4
SCHEMBL4076682 0.90 P2RY2 (0.54) P2RY6P2RY2DNPH1P2RY4
SCHEMBL2609977 0.89 P2RY6 (0.51) P2RY6P2RY2DNPH1P2RY4
SCHEMBL12714926 0.87 P2RY6 (0.72) P2RY6P2RY2DNPH1P2RY4
SCHEMBL15065276 0.87 P2RY6 (0.72) P2RY6P2RY2DNPH1P2RY4
SCHEMBL17979616 0.87 DNPH1 (0.81) P2RY6P2RY2DNPH1P2RY4
SCHEMBL14946379 0.87 DNPH1 (0.81) P2RY6P2RY2DNPH1P2RY4
SCHEMBL14929299 0.87 DNPH1 (0.81) P2RY6P2RY2DNPH1P2RY4
SCHEMBL15065277 0.87 P2RY6 (0.72) P2RY6P2RY2DNPH1P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression CureVac SE (DE) 2025-11-04 US claimed
US-20250136711-A1 SEMENOGELIN NEUTRALIZING ANTIBODY AND EPITOPE AND APPLICATION THEREOF SHANGHAI BIOTROY BIOTECHNIQUE CO., LTD (CN) 2025-05-01 US claimed
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE TRANSLATE BIO INC (US) 2024-12-19 US claimed
CN-118924887-A HPV MRNA LNP vaccine 南京吉迈生物技术有限公司 2024-11-12 CN claimed
US-20240336901-A1 Modification of 3' Terminal Ends of Nucleic Acids by DNA Polymerase Theta UNIV TEMPLE (US) 2024-10-10 US claimed
US-20240309447-A1 METHODS AND KITS FOR PREPARING A SAMPLE COMPRISING ONE OR MORE RNA MOLECULES FOR SEQUENCING THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2024-09-19 US claimed
US-11998601-B2 Messenger RNA therapy for treatment of articular disease TRANSLATE BIO, INC. (US) 2024-06-04 US claimed
US-11993791-B2 Modification of 3′ terminal ends of nucleic acids by DNA polymerase theta TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2024-05-28 US claimed
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression MODERNATX, INC. (US) 2024-05-14 US claimed
US-11951120-B2 Modification of gene transcription and translation efficiency by 5′UTR sequence variation Nanjing GeneLeap Biotechnology Co., Ltd. 2024-04-09 US claimed
WO-2008083949-A2 RNA-CODED ANTIBODY CUREVAC GMBH (DE) 2008-07-17 WO claimed
US-7229765-B2 Random-primed reverse transcriptase-in vitro transcription method for RNA amplification ROSETTA INPHARMATICS LLC (US) 2007-06-12 US claimed
US-20050214759-A1 Enzymatic redox labelling of nucleic acids WLASSOF WJATSCHESSLAW 2005-09-29 US claimed
US-20040081978-A1 Random-primed reverse transcriptase-in vitro transcription method for rna amplification Life Technologies Corporation 2004-04-29 US claimed
EP-0724647-A4 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME GILEAD SCIENCES INC (US) 2003-09-17 EP claimed
WO-2002044399-A2 IN VITRO TRANSCRIPTION METHOD FOR RNA AMPLIFICATION ROSETTA INPHARMATICS, INC. (US) 2002-06-06 WO claimed
US-5958691-A DETECTION OF NUCLEIC ACID LIGANDS WITH MODIFIED NUCLEOTIDE TO TARGET GROUPS, SINGLE STRAND NUCLEIC ACIDS AND PARTITIONING THE NUCLEIC ACIDS, AMPLIFICATION NEXSTAR PHARMACEUTICALS, INC. (US) 1999-09-28 US claimed
US-5660985-A CONTACTING MIXTURE OF MODIFIED SINGLE-STRANDED NUCLEIC ACIDS WITH TARGET MOLECULE, PARTITIONING THOSE WITH INCREASED AFFINITY, AMPLIFYING TO IDENTIFY LIGANDS OF TARGET MOLECULE NEXSTAR PHARMACEUTICALS, INC. (US) 1997-08-26 US claimed
EP-0724647-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NeXstar Pharmaceuticals, Inc. (US) 1996-08-07 EP claimed
WO-1995007364-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NEXSTAR PHARMACEUTICALS, INC. (US) 1995-03-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression RNMT, NSUN3, RNGTT P2RY6 2967/4885P2RY2 2992/4885DNPH1 3396/4885
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression RNGTT, UPF1, RNMT P2RY6 4640/4885P2RY2 4412/4885DNPH1 2503/4885
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE NSUN3, RNMT, TRDMT1 P2RY6 3298/4885P2RY2 3741/4885DNPH1 4191/4885
US-11998601-B2 Messenger RNA therapy for treatment of articular disease NSUN3, RNMT, TRDMT1 P2RY6 3298/4885P2RY2 3741/4885DNPH1 4191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.