Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989571 | 0.83 | KMT2A (0.41) | CES2CES1PTGS2ALDH1A1KDM4E | |
| SCHEMBL4434050 | 0.82 | PTGS2 (0.41) | PTGS2ALDH1A1ALOX15OPRM1OPRD1 | |
| SCHEMBL4427312 | 0.80 | ALDH1A1 (0.43) | PTGS2ALDH1A1ALOX15OPRM1OPRK1 | |
| SCHEMBL4430871 | 0.78 | KDM4E (0.40) | PTGS2ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL1944076 | 0.76 | PTGS2 (0.58) | PTGS2ALBALDH1A1ALOX15KDM4E | |
| SCHEMBL18302947 | 0.74 | CES2 (0.41) | CES2CES1PTGS2ALDH1A1ALOX15 | |
| SCHEMBL4991196 | 0.74 | HDAC4 (0.40) | CES2CES1OPRM1OPRD1OPRK1 | |
| SCHEMBL11634695 | 0.73 | PTGS2 (0.45) | PTGS2ALDH1A1ALOX15KDM4ECASP1 | |
| SCHEMBL4994701 | 0.71 | KDM4E (0.43) | CES2CES1ALDH1A1OPRM1OPRD1 | |
| SCHEMBL2621624 | 0.71 | ALDH1A1 (0.48) | PTGS2ALDH1A1ALOX15KDM4ECASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | ENCYSIVE PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | C3AR1, C5, C5AR1 | CES2 3338/4885CES1 2506/4885PTGS2 1716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.