Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MYB | P10242 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6762410 | 0.91 | CHRNA7 (0.48) | CHRNA7MAOBMYBEGFRSRC | |
| SCHEMBL3488326 | 0.91 | CHRNA7 (0.48) | CHRNA7MAOBMYBEGFRSRC | |
| SCHEMBL1656917 | 0.77 | CHRNA7 (0.48) | CHRNA7MAOBEGFRSRCKDR | |
| SCHEMBL4984639 | 0.77 | CHRNA7 (0.42) | SRD5A1SRD5A2CHRNA7PDGFRBPDGFRA | |
| SCHEMBL4984632 | 0.77 | CHRNA7 (0.42) | SRD5A1SRD5A2CHRNA7PDGFRBPDGFRA | |
| SCHEMBL7214919 | 0.77 | SRD5A1 (0.58) | SRD5A1SRD5A2PDGFRBPDGFRANPC1 | |
| SCHEMBL31757025 | 0.76 | CHRNA7 (0.51) | SRD5A1SRD5A2CHRNA7NPC1RAB9A | |
| SCHEMBL5253488 | 0.75 | SRC (0.54) | PDGFRBPDGFRAEGFRSRCKDR | |
| SCHEMBL1656955 | 0.74 | CTSV (0.54) | SRD5A1SRD5A2NPC1RAB9A | |
| SCHEMBL14966235 | 0.74 | CHRNA7 (0.45) | CHRNA7MAOBMYBEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100457719-C | Process for the regioselective preparation of substituted benzo [ G ] quinoline-3-carbonitriles and benzo [ G ] quinazolines | WYETH CORP (US) | 2009-02-04 | — | — | CN | disclosed |
| US-20080171874-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | WYETH (US) | 2008-07-17 | — | — | US | disclosed |
| US-7365197-B2 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
| US-20060041127-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | WYETH | 2006-02-23 | — | — | US | disclosed |
| CN-1483019-A | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | — | 2004-03-17 | — | — | CN | disclosed |
| EP-1345889-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO G]QUINOLINE-3-CARBONITRILES AND BENZO G]QUINAZOLINES | Wyeth (US) | 2003-09-24 | — | — | EP | disclosed |
| US-20020091273-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines | AMERICAN HOME PRODUCTS CORPORATION | 2002-07-11 | — | — | US | disclosed |
| WO-2002053528-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | WYETH (US) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171874-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | PDXK, PKD1, GLS | SRD5A1 1700/4885SRD5A2 1647/4885CHRNA7 4401/4885 |
| US-20060041127-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | PDXK, PKD1, GLS | SRD5A1 1700/4885SRD5A2 1647/4885CHRNA7 4401/4885 |
| US-20020091273-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines | PDXK, PKD1, PFKP | SRD5A1 1929/4885SRD5A2 1838/4885CHRNA7 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.