Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989307 | 0.93 | ALDH1A1 (0.46) | ALDH1A1HMOX1MAPTAKR1C3AKR1C1 | |
| SCHEMBL4986273 | 0.91 | PKM (0.42) | MAPTLMNAAKR1C3KMT2AL3MBTL1 | |
| SCHEMBL4986058 | 0.91 | USP2 (0.46) | ALDH1A1MAPTKMT2AL3MBTL1POLB | |
| SCHEMBL4988076 | 0.88 | KMT2A (0.49) | ALDH1A1KMT2AL3MBTL1POLBPKM | |
| SCHEMBL4991400 | 0.85 | EPHX2 (0.41) | ALDH1A1LMNAAKR1C3TP53EPHX2 | |
| SCHEMBL4992564 | 0.85 | MEN1 (0.47) | HMOX1MAPTLMNAAKR1C3AKR1C1 | |
| SCHEMBL4989380 | 0.85 | ALDH1A1 (0.39) | ALDH1A1MAPTAKR1C3KMT2AL3MBTL1 | |
| SCHEMBL4993377 | 0.85 | KMT2A (0.43) | MAPTLMNAAKR1C3AKR1C1KMT2A | |
| SCHEMBL4986044 | 0.84 | FAAH (0.39) | EPHX2 | |
| SCHEMBL4986102 | 0.83 | PKM (0.44) | AKR1C3KMT2AL3MBTL1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | ALDH1A1 3640/4885HMOX1 439/4885MAPT 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.