Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 12/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.55 |
| ▸ | ESRRG | P62508 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456940 | 0.82 | THRB (0.54) | LMNAHDAC8HDAC6MEN1KMT2A | |
| SCHEMBL12993420 | 0.82 | RAB9A (0.88) | LMNARAB9AEPHX2NR1H4ESRRG | |
| SCHEMBL4989466 | 0.78 | RAB9A (0.54) | LMNARAB9AEPHX2NR1H4HDAC3 | |
| SCHEMBL12049334 | 0.77 | ALOX12 (0.72) | LMNARAB9AMEN1KMT2AHTT | |
| SCHEMBL11954 | 0.76 | EPHX2 (0.59) | LMNARAB9AEPHX2NR1H4HDAC3 | |
| SCHEMBL4881597 | 0.75 | EPHX2 (0.60) | LMNARAB9AEPHX2NR1H4HDAC3 | |
| SCHEMBL7113776 | 0.75 | RAB9A (1.00) | LMNARAB9AEPHX2NR1H4HDAC3 | |
| SCHEMBL3536168 | 0.75 | LMNA (0.53) | LMNARAB9AEPHX2NR1H4ESRRG | |
| SCHEMBL4618832 | 0.74 | EPHX2 (0.68) | LMNARAB9AEPHX2NR1H4HDAC3 | |
| SCHEMBL4858212 | 0.73 | LMNA (0.68) | LMNARAB9AEPHX2NR1H4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171756-A1 | N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors | HIF1AN, EGLN2, EGLN3 | LMNA 3270/4885RAB9A 4020/4885EPHX2 1285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.