Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | RECQL | P46063 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | BLM | P54132 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | APEX1 | P27695 | 4/20 | 0.50 |
| ▸ | MTOR | P42345 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667494 | 0.79 | ESR1 (0.43) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL14303527 | 0.79 | TDP1 (0.62) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL11430514 | 0.79 | TDP1 (0.62) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL8470594 | 0.79 | ESR1 (0.43) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL13479446 | 0.79 | TDP1 (0.62) | TDP1KDM4EMAPTRECQLLMNA | |
| Hydrochloric Acid SCHEMBL17220823 | 0.77 | ALOX15 (0.44) | TDP1KDM4EMAPTLMNAAPEX1 | |
| SCHEMBL7845490 | 0.76 | TDP1 (0.53) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL11422792 | 0.76 | TDP1 (0.54) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL5050817 | 0.75 | MAPT (0.49) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL12498003 | 0.74 | SLC6A2 (0.50) | LMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139664-A1 | ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2008-06-12 | — | — | US | claimed |
| US-20050043408-A1 | Anti-glycation agents for preventing age- diabetes- and smoking-related complications | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2005-02-24 | — | — | US | claimed |
| EP-1435930-A2 | ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2004-07-14 | — | — | EP | claimed |
| WO-2003032969-A2 | ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2003-04-24 | — | — | WO | claimed |
| US-20080139664-A1 | ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2008-06-12 | — | — | US | disclosed |
| US-20050043408-A1 | Anti-glycation agents for preventing age- diabetes- and smoking-related complications | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043408-A1 | Anti-glycation agents for preventing age- diabetes- and smoking-related complications | AGER, GID4, GALE | TDP1 1731/4885KDM4E 1767/4885MAPT 1352/4885 |
| US-20080139664-A1 | ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS | AGER, GID4, GALE | TDP1 1717/4885KDM4E 1615/4885MAPT 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.