Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL58997 | 0.89 | MAPK1 (0.47) | MAPK1ALDH1A1TSHR | |
| Cyclohexane SCHEMBL65948 | 0.86 | — | — | |
| Methylene Chloride SCHEMBL7521557 | 0.83 | MAPK1 (0.42) | MAPK1ALDH1A1TSHR | |
| Ethyl Chloride SCHEMBL10588167 | 0.79 | MAPK1 (0.44) | MAPK1ALDH1A1TSHR | |
| Ethylene Glycol SCHEMBL3420637 | 0.78 | TSHR (0.32) | TSHR | |
| Ethylene Glycol SCHEMBL9733138 | 0.78 | TSHR (0.32) | TSHR | |
| Acetone SCHEMBL11413386 | 0.75 | TSHR (0.41) | MAPK1ALDH1A1TSHR | |
| Hexane SCHEMBL9455882 | 0.75 | TSHR (0.43) | MAPK1ALDH1A1TSHR | |
| Ether SCHEMBL15135184 | 0.75 | MAPK1 (0.36) | MAPK1 | |
| Chloromethane SCHEMBL11103401 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171885-A1 | Process for Preparation of Highly Pure Trandolapril | LUPIN LIMITED (IN) | 2008-07-17 | — | — | US | disclosed |
| EP-1866327-A1 | IMPROVED PROCESS FOR PREPARATION OF HIGHLY PURE TRANDOLAPRIL | Lupin Ltd. (IN) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006085332-A1 | IMPROVED PROCESS FOR PREPARATION OF HIGHLY PURE TRANDOLAPRIL | LUPIN LIMITED (IN) | 2006-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171885-A1 | Process for Preparation of Highly Pure Trandolapril | TPH1, HTR1A, HTR3A | MAPK1 2961/4885MEN1 4836/4885KMT2A 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.