Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | FNIP1 | Q8TF40 | 1/20 | 0.38 |
| ▸ | FEM1B | Q9UK73 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753733 | 0.85 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL10254268 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL499710 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL23818006 | 0.77 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL4754228 | 0.76 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL30797543 | 0.74 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL20400038 | 0.74 | BCL2A1 (0.44) | ALDH1A1SMN1; SMN2RAB9AHTTNPC1 | |
| SCHEMBL3651288 | 0.74 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL9525464 | 0.74 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA | |
| SCHEMBL8943566 | 0.73 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2RAB9AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100144825-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-06-10 | — | — | US | disclosed |
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144825-A1 | Renin Inhibitors | ACE, REN, DNPEP | ALDH1A1 1991/4885SMN1; SMN2 3254/4885RAB9A 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.