Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30388175 | 0.85 | GABRA2 (0.50) | TSHRMAPTGABRA2GABRB2ALDH1A1 | |
| SCHEMBL7735518 | 0.84 | ALDH1A1 (0.56) | TSHRMAPTGABRA2GABRB2ALDH1A1 | |
| SCHEMBL4433936 | 0.80 | CDC25B (0.50) | MAPTALDH1A1KDM4EHSD17B10LMNA | |
| SCHEMBL31456637 | 0.78 | NPC1 (0.54) | TSHRMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL1136978 | 0.76 | ALDH1A1 (0.60) | TSHRMAPTGABRA2ALDH1A1KDM4E | |
| SCHEMBL27686802 | 0.74 | TSHR (0.65) | TSHRMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL679127 | 0.73 | MAPT (0.61) | TSHRMAPTGABRA2GABRB2ALDH1A1 | |
| SCHEMBL4787448 | 0.73 | MAPT (0.54) | TSHRMAPTGABRA2GABRB2ALDH1A1 | |
| SCHEMBL30854470 | 0.73 | TSHR (0.58) | TSHRMAPTALDH1A1KDM4EHPGD | |
| Diethyl Phthalate SCHEMBL19252611 | 0.73 | TSHR (0.95) | TSHRALDH1A1KDM4EHSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | ENCYSIVE PHARMACEUTICALS, INC. | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188528-A1 | Modulators of C3a receptor and methods of use thereof | C3AR1, C5, C5AR1 | TSHR 294/4885MAPT 4654/4885GABRA2 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.