Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14115528 | 1.00 | SLC6A3 (0.56) | SLC6A3SLC6A2SLC6A4GABBR2GABBR1 | |
| SCHEMBL26326658 | 0.77 | SLC6A2 (0.58) | SLC6A3SLC6A2SLC6A4GABBR2GABBR1 | |
| SCHEMBL8102527 | 0.76 | SLC6A2 (0.58) | SLC6A3SLC6A2SLC6A4MAPTMEN1 | |
| SCHEMBL4963593 | 0.75 | SLC6A2 (0.70) | SLC6A3SLC6A2SLC6A4GABBR2GABBR1 | |
| Hydrochloric Acid SCHEMBL4994288 | 0.74 | SLC6A2 (0.69) | SLC6A3SLC6A2SLC6A4GABBR2GABBR1 | |
| SCHEMBL3663686 | 0.73 | SLC6A2 (0.54) | SLC6A3SLC6A2SLC6A4UGT2B7MEN1 | |
| SCHEMBL3732482 | 0.72 | SLC6A2 (1.00) | SLC6A3SLC6A2SLC6A4UGT2B7CYP2D6 | |
| SCHEMBL14115529 | 0.72 | SLC6A2 (0.66) | SLC6A3SLC6A2SLC6A4GABBR2GABBR1 | |
| SCHEMBL5001159 | 0.72 | SLC6A2 (1.00) | SLC6A3SLC6A2SLC6A4UGT2B7CYP2D6 | |
| SCHEMBL5001133 | 0.72 | SLC6A2 (1.00) | SLC6A3SLC6A2SLC6A4UGT2B7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200556-A1 | Amine Compounds And Inhibiting Neurotrasmitter Reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-08-21 | — | — | US | disclosed |