Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL819123 | 0.79 | LMNA (0.38) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL5009094 | 0.79 | MAPT (0.38) | LMNASMN1; SMN2L3MBTL1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL820651 | 0.69 | LMNA (0.41) | LMNASMN1; SMN2L3MBTL1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL819882 | 0.69 | KDM4E (0.40) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL3086287 | 0.69 | CCR1 (0.40) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| SCHEMBL16581166 | 0.68 | MMP2 (0.54) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL5000247 | 0.68 | LMNA (0.39) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL819935 | 0.66 | CCR1 (0.37) | LMNASMN1; SMN2GAAL3MBTL1KMT2A | |
| SCHEMBL6131338 | 0.66 | CCR1 (0.46) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| Hydrochloric Acid SCHEMBL5006801 | 0.64 | P2RX7 (0.45) | LMNASMN1; SMN2L3MBTL1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | BASELL POLYOLEFINE GMBH (DE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269445-A1 | Monocyclopentadienyl Complexes | PCBP1, COASY, PORCN | LMNA 2672/4885SMN1; SMN2 3981/4885GAA 4642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.