Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000547 | 0.94 | OPRM1 (0.42) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL4995872 | 0.91 | CHRM1 (0.41) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL5004161 | 0.90 | OPRM1 (0.41) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL4991406 | 0.84 | OPRM1 (0.58) | OPRM1KCNH2HSD11B1PLD1YEATS4 | |
| SCHEMBL5000817 | 0.84 | PLD2 (0.41) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL5004066 | 0.81 | CHRM1 (0.40) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL5000543 | 0.79 | PLD1 (0.42) | OPRM1CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL4437932 | 0.79 | YEATS4 (0.52) | KCNH2HSD11B1PLD1YEATS4DRD2 | |
| SCHEMBL4435813 | 0.78 | OPRM1 (0.57) | OPRM1CHRM1KCNH2HSD11B1PLD1 | |
| SCHEMBL4446718 | 0.78 | OPRM1 (0.42) | OPRM1CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | OPRM1 4069/4885CHRM1 2922/4885CHRM2 3679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.