Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 5/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | PLD2 | O14939 | 5/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436430 | 0.89 | CTSS (0.44) | YEATS4KCNH2CTSSHSD11B1HTR1A | |
| SCHEMBL4437888 | 0.83 | YEATS4 (0.42) | YEATS4KCNH2CTSSHSD11B1HTR1A | |
| SCHEMBL4440103 | 0.82 | CTSS (0.42) | YEATS4KCNH2CTSSHTR1AADRA2A | |
| SCHEMBL4438903 | 0.81 | YEATS4 (0.49) | YEATS4KCNH2CHRM2CHRM4CHRM5 | |
| SCHEMBL4438587 | 0.80 | YEATS4 (0.51) | YEATS4KCNH2CHRM2CHRM4CHRM5 | |
| SCHEMBL4446685 | 0.79 | CTSS (0.45) | CTSSCHRM1HSD11B1HTR1AADRA2A | |
| SCHEMBL4435287 | 0.77 | YEATS4 (0.51) | YEATS4KCNH2HSD11B1ALDH1A1HTR1A | |
| SCHEMBL5000779 | 0.77 | HTR1A (0.41) | YEATS4KCNH2CTSSCHRM1ALDH1A1 | |
| SCHEMBL4446518 | 0.76 | CTSS (0.44) | YEATS4KCNH2CTSSHSD11B1ALDH1A1 | |
| SCHEMBL4434784 | 0.76 | YEATS4 (0.68) | YEATS4KCNH2ALDH1A1DRD2PLD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | HTT 4000/4885YEATS4 1467/4885KCNH2 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.