Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736590 | 0.87 | LMNA (0.67) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL13055383 | 0.86 | LMNA (0.80) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL485753 | 0.86 | TGM2 (0.66) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL6253000 | 0.84 | LMNA (0.63) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL9115718 | 0.83 | LMNA (0.61) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL16553601 | 0.83 | HTT (0.62) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL18254066 | 0.83 | HTT (0.81) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL16299890 | 0.82 | LMNA (0.60) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| SCHEMBL9874334 | 0.81 | HTT (0.79) | LMNASMN1; SMN2HTTTGM2L3MBTL1 | |
| Benzyl Phenethylcarbamate SCHEMBL4287199 | 0.81 | LMNA (0.73) | LMNASMN1; SMN2HTTTGM2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111385-B1 | Substituted alkine derivatives as anti-cancer agents | UNIV LOUISVILLE RES FOUND (US) | 2014-11-12 | — | — | EP | disclosed |
| US-8703829-B2 | Therapeutic compounds | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| EP-2567950-A1 | Substituted alkine derivatives as anti-cancer agents | University Of Louisville Research Foundation, Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20120329866-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-12-27 | — | — | US | disclosed |
| US-8207381-B2 | 1-Bromo-1,1-difluoro-non-2-yn-4-ol; 6-Bromo-6,6-difluoro-2,2-dimethyl-hex-4-yn-3-ol; anticarcinogenic, -tumor, -metastasic agents; enzyme inhibitors of modification methylases; myelodysplastic syndrome, leukemia, a solid tumor, schizophrenia, sickle cell disease, or lupus; breast, colon, brain cancers | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION (US) | 2012-06-26 | — | — | US | disclosed |
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188570-A1 | THERAPEUTIC COMPOUNDS | ABCB1, NQO1, ABCB11 | LMNA 1586/4885SMN1; SMN2 78/4885HTT 447/4885 |
| US-20120329866-A1 | THERAPEUTIC COMPOUNDS | ABCB1, MCL1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | LMNA 1925/4885SMN1; SMN2 68/4885HTT 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.