Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | XDH | P47989 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13790444 | 0.85 | CYP17A1 (0.49) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5011669 | 0.85 | KDM4E (0.59) | TSHRSMN1; SMN2HTTCYP1A2CYP2C19 | |
| SCHEMBL5007638 | 0.85 | XDH (0.47) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5007676 | 0.84 | XDH (0.48) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5007643 | 0.82 | XDH (0.64) | TSHRHTTXDHCYP1A2CYP2C19 | |
| SCHEMBL5009703 | 0.82 | NPC1 (0.48) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5009869 | 0.81 | CYP17A1 (0.51) | TSHRSMN1; SMN2CYP1A2POLBCYP2D6 | |
| SCHEMBL5009708 | 0.77 | GRM1 (0.51) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5011591 | 0.77 | XDH (0.42) | TSHRSMN1; SMN2HTTXDHCYP1A2 | |
| SCHEMBL5009196 | 0.77 | ADORA1 (0.47) | SMN1; SMN2KDM4ELMNARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| WO-2007054294-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | NOD1, FPR3, FPR1 | TSHR 3047/4885SMN1; SMN2 3907/4885HTT 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.