SCHEMBL5009232

SCHEMBL5009232

CC(C)(C)c1ccc2c(c1)C=NCC2

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
HTR1D P28221 2/20 0.32
ADRA1A P35348 2/20 0.32
ADRA2A P08913 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
ADRA1D P25100 1/20 0.32
HTR1B P28222 1/20 0.32
ADRA1B P35368 1/20 0.32
MAPT P10636 2/20 0.32
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
PKM P14618 1/20 0.32
RECQL P46063 1/20 0.32
KMT2A Q03164 1/20 0.32
NISCH Q9Y2I1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6968191 0.86
SCHEMBL28179870 0.82 PARP1 (0.38)
SCHEMBL137957 0.81 ALDH1A1 (0.36) ALDH1A1HPGDALOX15HSD17B10TDP1
SCHEMBL4724433 0.76 ADRA2A (0.34) ALDH1A1ADRA2AMAPTGAAPKM
SCHEMBL20504308 0.74
SCHEMBL28061563 0.73 KIF11 (0.46) NISCH
Hydrochloric Acid SCHEMBL11652402 0.73
SCHEMBL7659749 0.72 MEN1 (0.34) ALDH1A1HPGDHSD17B10ADRA2AMAPT
SCHEMBL9572969 0.72 ADRA2A (0.39) ADRA2AADRA2BADRA2CKMT2A
SCHEMBL6161601 0.72 TRPA1 (0.45) TDP1ADRA2AADRA2BADRA2CL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080274879-A1 Process of producing an organic catalyst HILER GEORGE DOUGLAS 2008-11-06 US disclosed
EP-1680404-A1 PROCESS FOR PRODUCING DIHYDROISOQUINOLINE ZWITTERIONS The Procter & Gamble Company (US) 2006-07-19 EP disclosed
US-20050113246-A1 Process of producing an organic catalyst THE PROCTER & GAMBLE COMPANY 2005-05-26 US disclosed
WO-2005047264-A1 PROCESS FOR PRODUCING DIHYDROISOQUINOLINE ZWITTERIONS THE PROCTER & GAMBLE COMPANY (US) 2005-05-26 WO disclosed