Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4986155 | 0.74 | PLAU (0.40) | PLAULMNATSHR | |
| SCHEMBL4985659 | 0.67 | MEN1 (0.42) | PLAU | |
| SCHEMBL7281533 | 0.67 | ALDH1A1 (0.60) | ALDH1A1HPGDLMNATSHRMAPK1 | |
| SCHEMBL30908640 | 0.66 | NOS1 (0.42) | PLAUALDH1A1LMNA | |
| SCHEMBL9925939 | 0.66 | BACE1 (0.58) | PLAUALDH1A1HPGDLMNA | |
| SCHEMBL21244063 | 0.66 | ALOX5AP (0.51) | ALDH1A1HPGDLMNAHCRTR1HCRTR2 | |
| SCHEMBL5664871 | 0.65 | PLAU (0.38) | PLAULMNATSHR | |
| Hydrochloric Acid SCHEMBL23646295 | 0.65 | ALOX5AP (0.50) | ALDH1A1HPGDLMNAHCRTR1HCRTR2 | |
| SCHEMBL7288618 | 0.65 | TSHR (0.61) | ALDH1A1HPGDLMNATSHRMAPK1 | |
| SCHEMBL29822323 | 0.64 | TP53 (0.69) | ALDH1A1HPGDLMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468378-B2 | Substituted quinoline compounds | PFIZER INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20050234099-A1 | Substituted quinoline compounds | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234099-A1 | Substituted quinoline compounds | APOB, APOL1, MTPN | PLAU 3855/4885ALDH1A1 2807/4885HPGD 3106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.