SCHEMBL5010264

SCHEMBL5010264

COc1nc(C)cnc1-c1ccc(F)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 1/20 0.41
PDGFRA P16234 1/20 0.41
DYRK1A Q13627 1/20 0.40
ALDH1A1 P00352 3/20 0.40
CYP1A2 P05177 2/20 0.40
MEN1 O00255 1/20 0.40
GLA P06280 1/20 0.40
CYP3A4 P08684 1/20 0.40
KMT2A Q03164 1/20 0.40
HIF1A Q16665 1/20 0.40
HSD17B10 Q99714 1/20 0.40
SQOR Q9Y6N5 5/20 0.40
TSHR P16473 1/20 0.39
MAPK14 Q16539 2/20 0.38
GRIA1 P42261 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA2B P29275 1/20 0.38
ADORA1 P30542 1/20 0.38
TDO2 P48775 2/20 0.38
IDO1 P14902 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5002006 0.83 SMN1; SMN2 (0.53) ALDH1A1MEN1GLAKMT2ASQOR
SCHEMBL1999851 0.80 ADORA1 (0.46) CYP1A2CYP3A4HSD17B10MAPK14ADORA2A
SCHEMBL4752099 0.79 JAK3 (0.57) CYP1A2MEN1CYP3A4KMT2AHSD17B10
SCHEMBL5010236 0.75 MAPK14 (0.45) CYP1A2MEN1CYP3A4KMT2ASQOR
SCHEMBL10508434 0.70 ALDH1A1 (0.51) DYRK1AALDH1A1MEN1KMT2A
SCHEMBL22874410 0.70 MEN1 (0.41) PDGFRBPDGFRADYRK1AALDH1A1MEN1
SCHEMBL15233567 0.69 CCR4 (0.38) ALDH1A1MEN1KMT2AHSD17B10SQOR
SCHEMBL3212419 0.69 JAK3 (0.54) DYRK1AALDH1A1MEN1KMT2AJAK3
SCHEMBL15577667 0.68 KMO (0.40) PDGFRBPDGFRAMAPK14TDO2IDO1
SCHEMBL29476058 0.68 JAK3 (0.53) DYRK1AALDH1A1MEN1KMT2AJAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541574-B2 Organometallic complex, and light-emitting element, light-emitting device and electronic device using the organometallic complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-24 US disclosed
US-8541574-B2 Organometallic complex, and light-emitting element, light-emitting device and electronic device using the organometallic complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-24 US disclosed
US-8541574-B2 Organometallic complex, and light-emitting element, light-emitting device and electronic device using the organometallic complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-09-24 US disclosed
US-20130079516-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-03-28 US disclosed
US-20130079516-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-03-28 US disclosed
US-20130079516-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2013-03-28 US disclosed
US-20080312437-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABRATORY CO., LTD. 2008-12-18 US disclosed
US-20080312437-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABRATORY CO., LTD. 2008-12-18 US disclosed
US-20080312437-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex SEMICONDUCTOR ENERGY LABRATORY CO., LTD. 2008-12-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080312437-A1 Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex NR2E3, AP2M1, AP3M1 PDGFRB 1814/4885PDGFRA 865/4885DYRK1A 4767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.