Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 2/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013591 | 0.88 | TSHR (0.47) | LMNAFAAHTRPV1ALDH1A1MAPT | |
| SCHEMBL5011711 | 0.80 | MAPT (0.46) | LMNAFAAHTRPV1ALDH1A1MAPT | |
| SCHEMBL5015097 | 0.76 | ALDH1A1 (0.42) | LMNAFAAHTRPV1ALDH1A1MAPT | |
| SCHEMBL4257512 | 0.74 | LMNA (0.48) | LMNAFAAHTRPV1ALDH1A1MAPT | |
| SCHEMBL4032463 | 0.66 | CCR3 (0.47) | LMNAFAAHALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1223807 | 0.65 | RAB9A (0.67) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL9818694 | 0.65 | CNR1 (0.62) | ALDH1A1MAPTRAB9AL3MBTL1NPC1 | |
| SCHEMBL16383892 | 0.65 | KDM4E (0.74) | LMNAFAAHTRPV1ALDH1A1MAPT | |
| SCHEMBL12478886 | 0.64 | ACHE (0.60) | LMNAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL5011708 | 0.64 | CYP1A2 (0.45) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |