SCHEMBL5011920

SCHEMBL5011920

Cc1cc(NC(C)Cc2ccccc2)ccc1C(c1ccc(N(C)C)cc1)c1ccc(NC(C)Cc2ccccc2)cc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
KMT2A Q03164 2/20 0.44
CNR2 P34972 1/20 0.38
SIGMAR1 Q99720 5/20 0.36
TAAR1 Q96RJ0 3/20 0.36
SLC18A2 Q05940 1/20 0.36
KDM1A O60341 1/20 0.35
SLC6A3 Q01959 2/20 0.35
MMP9 P14780 1/20 0.35
PLAUR Q03405 1/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.34
MAPT P10636 1/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
MAPK1 P28482 1/20 0.34
RAB9A P51151 1/20 0.34
NFKB2 Q00653 1/20 0.34
RELA Q04206 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5011802 0.89 MEN1 (0.46) ALDH1A1KMT2ACNR2SIGMAR1TAAR1
SCHEMBL5010076 0.85 ALDH1A1 (0.51) ALDH1A1KMT2ACNR2SIGMAR1TAAR1
SCHEMBL5010102 0.84 KMT2A (0.50) ALDH1A1KMT2ASIGMAR1GAAMAPT
SCHEMBL5011774 0.81 MEN1 (0.45) ALDH1A1KMT2ACNR2SIGMAR1TAAR1
SCHEMBL3903241 0.78 HTT (0.34) ALDH1A1KMT2AGAAMAPTACACB
SCHEMBL5011925 0.78 SMN1; SMN2 (0.44) ALDH1A1KMT2ACNR2SLC6A3SMN1; SMN2
SCHEMBL5009568 0.77 GAA (0.45) KMT2ASIGMAR1TAAR1SLC18A2GAA
SCHEMBL5667990 0.76 G6PD (0.43) ALDH1A1KMT2ASIGMAR1TAAR1SLC18A2
SCHEMBL3905889 0.74 SIGMAR1 (0.54) ALDH1A1KMT2ASIGMAR1TAAR1SLC18A2
SCHEMBL5011838 0.73 MEN1 (0.53) ALDH1A1KMT2ACNR2SIGMAR1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080311524-A1 Method For Making Negative-Working Heat-Sensitive Lithographic Printing Plate Precursor AGFA GRAPHICS N.V. (BE) 2008-12-18 US disclosed
US-20060078802-A1 Holographic storage medium SABIC INNOVATIVE PLASTICS IP B.V. 2006-04-13 US disclosed
EP-0239868-B1 PHOTOCHROMIC SYSTEM, LAYER PREPARED THEREOF AND ITS USE BASF Aktiengesellschaft (DE) 1989-12-27 EP disclosed
US-4857438-A Photochromic system and layers produced therewith BASF AKTIENGESELLSCHAFT (DE) 1989-08-15 US disclosed
EP-0239868-A1 Photochromic system, layer prepared thereof and its use BASF Aktiengesellschaft (DE) 1987-10-07 EP disclosed
US-4332884-A USING A DIOXIME CHELATING AGENT RICOH CO., LTD. (JP) 1982-06-01 US disclosed
US-4306014-A AMMONIA OR AMINES SUPPRESS THE COLOR-FORMING REACTION SYSTEM RICOH CO., LTD. (JP) 1981-12-15 US disclosed
US-4251619-A Process for forming photo-polymeric image KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-02-17 US disclosed