Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014328 | 0.81 | METAP2 (0.50) | KEAP1L3MBTL1GLO1MAPTHTT | |
| SCHEMBL5892150 | 0.79 | IDO1 (0.34) | KMT2ATSHR | |
| SCHEMBL8667928 | 0.79 | KDM4E (0.32) | L3MBTL1MAPTHSD17B10KDM4E | |
| SCHEMBL157836 | 0.75 | KEAP1 (0.47) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 | |
| SCHEMBL2079440 | 0.75 | KEAP1 (0.52) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 | |
| SCHEMBL5015626 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 | |
| SCHEMBL5015645 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 | |
| SCHEMBL1046017 | 0.74 | KEAP1 (0.46) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 | |
| SCHEMBL3715386 | 0.74 | PLA2G7 (0.54) | KEAP1NFE2L2L3MBTL1PTGS1NR3C1 | |
| SCHEMBL5015655 | 0.74 | EP300 (0.46) | KEAP1NFE2L2L3MBTL1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |