Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | IL1RN | P18510 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012855 | 0.81 | KEAP1 (0.42) | TSHRKMT2AGLO1GAAHTT | |
| SCHEMBL10438570 | 0.78 | ALDH1A1 (0.57) | METAP2ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL4573379 | 0.78 | ALDH1A1 (0.54) | METAP2ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL28800836 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2TSHRKMT2ARECQL | |
| SCHEMBL28740683 | 0.74 | ALDH1A1 (0.57) | METAP2ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL2207251 | 0.74 | METAP2 (0.48) | METAP2ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL2207344 | 0.74 | METAP2 (0.48) | METAP2ALDH1A1SMN1; SMN2TSHRKMT2A | |
| SCHEMBL8667928 | 0.74 | KDM4E (0.32) | ALDH1A1RECQLPOLBUSP2MAPT | |
| SCHEMBL5892150 | 0.74 | IDO1 (0.34) | TSHRKMT2ARECQLUSP2 | |
| SCHEMBL2067538 | 0.73 | ALDH1A1 (0.68) | METAP2ALDH1A1SMN1; SMN2KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |