Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 11/20 | 0.50 |
| ▸ | CDK2 | P24941 | 10/20 | 0.50 |
| ▸ | CDK3 | Q00526 | 9/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015389 | 0.81 | DEGS1 (0.48) | CCNE1CDK2ADORA3ADORA1MEN1 | |
| SCHEMBL28340206 | 0.81 | MAP3K5 (0.51) | CCNE1CDK2CDK3ADORA3ADORA1 | |
| SCHEMBL5022949 | 0.81 | ADORA3 (0.43) | CCNE1CDK2CDK3ADORA3ADORA1 | |
| SCHEMBL5017650 | 0.76 | NPC1 (0.55) | CDK2ADORA3ADORA1MEN1ALDH1A1 | |
| SCHEMBL3415683 | 0.74 | CDK2 (0.55) | CCNE1CDK2MAPTRAB9AAURKA | |
| SCHEMBL3651264 | 0.73 | ROCK2 (0.43) | CDK2MEN1MAPTRAB9AKMT2A | |
| SCHEMBL5014078 | 0.71 | SMN1; SMN2 (0.57) | ALDH1A1LMNAMAPTRAB9AKMT2A | |
| SCHEMBL1561387 | 0.71 | MAPT (0.70) | ERCC1ERCC4MEN1ALDH1A1LMNA | |
| SCHEMBL31412961 | 0.70 | ROCK2 (0.47) | CDK2ADORA3ADORA1ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL11858514 | 0.69 | MAPT (0.68) | ERCC1ERCC4MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234262-A1 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | MTOR, PIK3CA, PDPK1 | CCNE1 2656/4885CDK2 222/4885CDK3 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.