SCHEMBL5014352

SCHEMBL5014352

C=CCc1c(O)ccc(C#N)c1O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 1/20 0.41
XDH P47989 1/20 0.39
ALDH1A1 P00352 5/20 0.38
KDM4E B2RXH2 5/20 0.38
MAPT P10636 4/20 0.38
HPGD P15428 4/20 0.38
GABRA1 P14867 3/20 0.38
GABRB2 P47870 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
AKR1B1 P15121 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
ALDH2 P05091 1/20 0.38
GAA P10253 1/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
PPARG P37231 1/20 0.38
PPARD Q03181 1/20 0.38
TNKS O95271 1/20 0.36
PARP1 P09874 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34464532 0.83 GABRA1 (0.33) XDHKDM4EMAPTGABRA1GABRB2
SCHEMBL31467839 0.83 TRPV4 (0.33) XDHALDH1A1KDM4EHPGDGABRA1
SCHEMBL7636228 0.83 SRD5A1 (0.39) SRD5A1XDHALDH1A1KDM4EMAPT
SCHEMBL10390703 0.79 GABRA1 (0.38) SRD5A1XDHALDH1A1KDM4EMAPT
SCHEMBL1413853 0.78 SRD5A1 (0.49) SRD5A1XDHALDH1A1KDM4EMAPT
SCHEMBL4163305 0.78 SRD5A1 (0.42) SRD5A1XDHALDH1A1KDM4EMAPT
SCHEMBL6550866 0.76 IMPDH2 (0.36) XDHKDM4EMAPTGABRA1GABRB2
SCHEMBL323547 0.76 XDH (0.54) SRD5A1XDHALDH1A1KDM4EMAPT
Hydrogen Sulfide SCHEMBL6721312 0.74 XDH (0.52) SRD5A1XDHALDH1A1KDM4EMAPT
SCHEMBL4012043 0.73 GABRA1 (0.52) SRD5A1XDHALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506162-B1 SYNTHESIS OF BENZONITRILES AND BENZIMIDATES GENZYME CORP (US) 2008-11-26 EP disclosed
EP-1506162-A2 SYNTHESIS OF BENZONITRILES AND BENZIMIDATES Genzyme Corporation (US) 2005-02-16 EP disclosed
WO-2003097582-A3 SYNTHESIS OF BENZONITRILES AND BENZIMIDATES GENZYME CORP (US) 2004-02-12 WO disclosed
WO-2003097582-A2 SYNTHESIS OF BENZONITRILES AND BENZIMIDATES GENZYME CORPORATION (US) 2003-11-27 WO disclosed