Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060789 | 0.79 | PTPN1 (0.41) | ALDH1A1P2RX7TMEM97SMN1; SMN2 | |
| SCHEMBL5013535 | 0.79 | ALDH1A1 (0.39) | MAPK8ALDH1A1SIGMAR1TMEM97SMN1; SMN2 | |
| SCHEMBL5013588 | 0.77 | HSD11B1 (0.42) | KMT2AALDH1A1MEN1SIGMAR1LMNA | |
| SCHEMBL1086126 | 0.76 | KMT2A (0.41) | KMT2AMAPK8MAPK10MRGPRX4SMN1; SMN2 | |
| SCHEMBL5012778 | 0.74 | TP53 (0.37) | KMT2AALDH1A1SIGMAR1LMNASMN1; SMN2 | |
| SCHEMBL5011835 | 0.73 | CYP1A2 (0.43) | ALDH1A1LMNA | |
| SCHEMBL5016389 | 0.73 | ALDH1A1 (0.35) | ALDH1A1TSHRL3MBTL1SIGMAR1TMEM97 | |
| SCHEMBL5016419 | 0.70 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1P2RX7SIGMAR1 | |
| SCHEMBL5011651 | 0.67 | CHRM2 (0.44) | KMT2AALDH1A1MEN1TSHRL3MBTL1 | |
| SCHEMBL5011764 | 0.67 | HTT (0.44) | KMT2AALDH1A1MEN1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |