SCHEMBL5015356

SCHEMBL5015356

CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12

nearest known ligand 0.76

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 1/20 0.76
TACR1 P25103 16/20 0.64
NPY5R Q15761 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5015355 1.00 GHSR (0.76) GHSRTACR1NPY5R
SCHEMBL29440089 1.00 GHSR (0.76) GHSRTACR1NPY5R
SCHEMBL5016439 0.95 GHSR (0.78) GHSRTACR1NPY5R
SCHEMBL5016442 0.95 GHSR (0.78) GHSRTACR1NPY5R
SCHEMBL6802758 0.88 GHSR (0.84) GHSRTACR1
SCHEMBL5013809 0.87 GHSR (0.76) GHSRTACR1NPY5R
SCHEMBL8843020 0.87 GHSR (0.76) GHSRTACR1NPY5R
SCHEMBL7381269 0.87 GHSR (0.76) GHSRTACR1NPY5R
SCHEMBL5013586 0.86 GHSR (0.70) GHSRTACR1NPY5R
SCHEMBL5013587 0.86 GHSR (0.70) GHSRTACR1NPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7442706-B2 Methods for treating sarcopenia with a growth hormone secretagogue AMMONETT PHARMA, LLC 2008-10-28 US claimed
US-20070219226-A1 METHODS FOR TREATING SARCOPENIA WITH A GROWTH HORMONE SECRETAGOGUE AMMONETT PHARMA, LLC 2007-09-20 US claimed
EP-0615977-B1 Spiro piperidines and homologs which promote release of growth hormone MERCK & CO INC (US) 2002-07-03 EP claimed
US-6194402-B1 ADMINISTERING A COMPOUND TO STIMULATE THE EFFECTS OF SOMATOTROPINS TO PATIENTS AFTER ACUTE DECONDITIONING SUCH AS THAT WHICH MAY RESULT FROM IMMOBILIZATION, SURGERY, OR MAJOR INJURY, E.G., HIP FRACTURE; MERCK & CO., INC. 2001-02-27 US claimed
US-6043026-A MIXTURE OF AN ESTROGEN RECEPTOR MODULATOR AND A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 2000-03-28 US claimed
WO-1998046220-A1 COMBINATION THERAPY FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS MERCK & CO., INC. (US) 1998-10-22 WO claimed
US-5536716-A Spiro piperidines and homologs which promote release of growth hormone MERCK & CO., INC. (US) 1996-07-16 US claimed
WO-1995011029-A1 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES MERCK & CO., INC. (US) 1995-04-27 WO claimed
EP-0615977-A1 Spiro piperidines and homologs which promote release of growth hormone MERCK & CO. INC. (US) 1994-09-21 EP claimed
US-20200261541-A1 METHODS OF TREATING MILD BRAIN INJURY OXEIA BIOPHARMACEUTICALS, INC. (US) 2020-08-20 US disclosed
US-20170281732-A1 METHODS OF TREATING MILD BRAIN INJURY OXEIA BIOPHARMACEUTICALS, INC. (US) 2017-10-05 US disclosed
US-20170266257-A1 METHODS OF TREATING TRAUMATIC BRAIN INJURY OXEIA BIOPHARMACEUTICALS, INC. (US) 2017-09-21 US disclosed
EP-3197482-A1 METHODS OF TREATING TRAUMATIC BRAIN INJURY Oxeia Biopharmaceuticals Inc. (US) 2017-08-02 EP disclosed
US-20170121385-A1 METHODS OF TREATING NEURODEGENERATIVE CONDITIONS OXEIA BIOPHARMACEUTICALS, INC. (US) 2017-05-04 US disclosed
US-5652235-A Method of using spiro piperidines to promote the release of growth hormone MERCK & CO., INC. (US) 1997-07-29 US disclosed
WO-1997021703-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed
US-5536716-A Spiro piperidines and homologs which promote release of growth hormone MERCK & CO., INC. (US) 1996-07-16 US disclosed
WO-1995011029-A1 COMBINATION OF BISPHOSPHONATES AND GROWTH HORMONE SECRETAGOGUES MERCK & CO., INC. (US) 1995-04-27 WO disclosed
EP-0615977-A1 Spiro piperidines and homologs which promote release of growth hormone MERCK & CO. INC. (US) 1994-09-21 EP disclosed
WO-1994013696-A1 SPIRO PIPERIDINES AND HOMOLOGS WHICH PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-06-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170266257-A1 METHODS OF TREATING TRAUMATIC BRAIN INJURY ATP6V1B2, FABP7, GHSR GHSR 3/4885TACR1 96/4885NPY5R 11/4885
US-20200261541-A1 METHODS OF TREATING MILD BRAIN INJURY FABP7, PYGB, ATP6V1B2 GHSR 47/4885TACR1 553/4885NPY5R 66/4885
US-20170121385-A1 METHODS OF TREATING NEURODEGENERATIVE CONDITIONS HTT, SNCA, NLN GHSR 64/4885TACR1 843/4885NPY5R 119/4885
US-20170281732-A1 METHODS OF TREATING MILD BRAIN INJURY ATP6V1B2, GHSR, CRH GHSR 2/4885TACR1 223/4885NPY5R 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.