Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.84 |
| ▸ | TACR1 known ✓ | P25103 | 19/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibutamoren SCHEMBL29366896 | 0.92 | GHSR (0.98) | GHSRTACR1 | |
| Ibutamoren SCHEMBL4451194 | 0.92 | GHSR (0.98) | GHSRTACR1 | |
| Ibutamoren SCHEMBL5013536 | 0.92 | GHSR (0.98) | GHSRTACR1 | |
| Ibutamoren SCHEMBL4927761 | 0.92 | GHSR (1.00) | GHSRTACR1 | |
| Ibutamoren SCHEMBL29369919 | 0.92 | GHSR (1.00) | GHSRTACR1 | |
| Ibutamoren SCHEMBL739398 | 0.92 | GHSR (1.00) | GHSRTACR1 | |
| Ibutamoren SCHEMBL7413830 | 0.91 | GHSR (0.98) | GHSRTACR1 | |
| Ibutamoren SCHEMBL7413834 | 0.91 | GHSR (0.98) | GHSRTACR1 | |
| SCHEMBL5016442 | 0.89 | GHSR (0.78) | GHSRTACR1 | |
| SCHEMBL5016439 | 0.89 | GHSR (0.78) | GHSRTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063641-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2004-04-01 | — | — | US | claimed |
| US-20020128178-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2002-09-12 | — | — | US | claimed |
| EP-0941115-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1999-09-15 | — | — | EP | claimed |
| WO-1998019699-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1998-05-14 | — | — | WO | claimed |
| US-20040063641-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2004-04-01 | — | — | US | disclosed |
| US-20020128178-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | RASCHKE MICHAEL (DE) | 2002-09-12 | — | — | US | disclosed |
| EP-0941115-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998019699-A1 | USE OF GROWTH HORMONE OR A GROWTH HORMONE SECRETAGOGUE FOR PROMOTING BONE FORMATION | NOVO NORDISK A/S (DK) | 1998-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063641-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | GHSR, GHRHR, BMP2 | GHSR 1/4885TACR1 502/4885 |
| US-20020128178-A1 | Use of growth hormone or a growth hormone secretagogue for promoting bone formation | GHSR, GHRHR, BMP2 | GHSR 1/4885TACR1 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.