Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 7/20 | 0.44 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151570 | 0.98 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL2275704 | 0.98 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL151569 | 0.98 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1ACERENLMNA | |
| Hydrochloric Acid SCHEMBL9148101 | 0.96 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACERENLMNA | |
| Lithium SCHEMBL593022 | 0.96 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACERENLMNA | |
| Hydrochloric Acid SCHEMBL9432225 | 0.96 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL593020 | 0.96 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL5434462 | 0.92 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL315372 | 0.92 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1ACERENLMNA | |
| SCHEMBL2158601 | 0.92 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1ACERENLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513871-B1 | PYRROLIDINYL PEPTIDE NUCLEIC ACIDS | ISIS INNOVATION (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-7098321-B2 | Homologous peptide nucleic acids | ISIS INNOVATION LIMITED (GB) | 2006-08-29 | — | — | US | disclosed |
| EP-1513871-A2 | PYRROLIDINYL PEPTIDE NUCLEIC ACIDS | Isis Innovation Limited (GB) | 2005-03-16 | — | — | EP | disclosed |
| US-6716961-B2 | Chiral peptide nucleic acids with a N-aminoethyl-d-proline backbone | ISIS INNOVATION LIMITED (GB) | 2004-04-06 | — | — | US | disclosed |
| US-20030228588-A1 | Homologous peptide nucleic acids | ISIS INNOVATION LIMITED | 2003-12-11 | — | — | US | disclosed |
| US-20030162699-A1 | Chiral peptide nucleic acids with a n-aminoethyl-d-proline backbone | ISIS INNOVATION LIMITED (GB) | 2003-08-28 | — | — | US | disclosed |
| US-20030157500-A1 | Pyrrolidinyl peptide nucleic acids | ISIS INNOVATION LIMITED (GB) | 2003-08-21 | — | — | US | disclosed |
| WO-2003066902-A2 | PYRROLIDINYL PEPTIDE NUCLEIC ACIDS | ISIS INNOVATION LIMITED (GB) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030157500-A1 | Pyrrolidinyl peptide nucleic acids | POLRMT, POLH, PCNA | ALDH1A1 3987/4885L3MBTL1 554/4885ACE 3500/4885 |
| US-20030162699-A1 | Chiral peptide nucleic acids with a n-aminoethyl-d-proline backbone | POLL, HNRNPL, RNGTT | ALDH1A1 4356/4885L3MBTL1 461/4885ACE 391/4885 |
| US-20030228588-A1 | Homologous peptide nucleic acids | HNRNPH3, PCNA, POLL | ALDH1A1 3963/4885L3MBTL1 305/4885ACE 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.