SCHEMBL502278

SCHEMBL502278

CC1OC(=O)C=C1N(C=CF)Cc1ccc(Cl)nc1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
PSEN1 P49768 1/20 0.30
PSEN2 P49810 1/20 0.30
APH1B Q8WW43 1/20 0.30
NCSTN Q92542 1/20 0.30
APH1A Q96BI3 1/20 0.30
PSENEN Q9NZ42 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL502277 1.00 ALDH1A1 (0.34) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL21462548 1.00 ALDH1A1 (0.34) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL2891247 0.81 ALDH1A1 (0.39) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL28773340 0.79 ALDH1A1 (0.35) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL501878 0.78 ALDH1A1 (0.34) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL29728026 0.78 ALDH1A1 (0.34) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL9961385 0.75 CHRNA1 (0.31) ALDH1A1PSEN1PSEN2APH1BNCSTN
SCHEMBL9961384 0.75 CHRNA1 (0.31) ALDH1A1PSEN1PSEN2APH1BNCSTN
SCHEMBL1165316 0.72 LMNA (0.37) ALDH1A1LMNAL3MBTL1PSEN1PSEN2
SCHEMBL1798274 0.66 PSEN1 (0.32) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114667062-A Pesticidal mixture formulations comprising glycol ether solvents 拜耳公司 2022-06-24 CN claimed
CN-111970927-B Insecticidal mixture formulations comprising propylene carbonate 拜耳公司 2025-03-14 CN disclosed
CN-114667062-B Insecticidal mixture formulations comprising glycol ether solvents 拜耳公司 2024-12-31 CN disclosed
CN-114667062-A Pesticidal mixture formulations comprising glycol ether solvents 拜耳公司 2022-06-24 CN disclosed
EP-2004635-B1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS BAYER IP GMBH (DE) 2015-09-23 EP disclosed
EP-2327304-B1 Use of substituted enaminocarbonyl compounds for combating animal pests BAYER CROPSCIENCE AG (DE) 2014-08-06 EP disclosed
US-8546577-B2 Substituted enaminocarbonyl compounds BAYER CROPSCIENCE AG (DE) 2013-10-01 US disclosed
US-8404855-B2 Substituted enaminocarbonyl compounds BAYER CROPSCIENCE AG (DE) 2013-03-26 US disclosed
US-20120157498-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2012-06-21 US disclosed
US-8106211-B2 Substituted enaminocarbonyl compounds BAYER CROPSCIENCE AG (DE) 2012-01-31 US disclosed
EP-2327304-A1 Use of substituted enaminocarbonyl compounds for combating animal pests Bayer CropScience AG (DE) 2011-06-01 EP disclosed
US-20090253749-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS BAYER CROPSCIENCE AG 2009-10-08 US disclosed
EP-2004635-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS Bayer CropScience AG (DE) 2008-12-24 EP disclosed
WO-2007115644-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS BAYER CROPSCIENCE AG (DE) 2007-10-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120157498-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS DDT, NPEPPS, L3MBTL4 ALDH1A1 4014/4885LMNA 494/4885L3MBTL1 12/4885
US-20090253749-A1 SUBSTITUTED ENAMINOCARBONYL COMPOUNDS DDT, NPEPPS, L3MBTL4 ALDH1A1 4014/4885LMNA 494/4885L3MBTL1 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.